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B6;129S4-Eomestm1.1(cre/ERT2)Zjh/J
Cat. No.: CEMM-07251053
Common Name: Tbr2-2A-CreER
Tbr2-2A-CreER knock-in mice express tamoxifen-inducible CreERT2 fusion protein from the mouse Eomes (eomesodermin; also called Tbr2) promoter in EOMES-positive cortical glutamatergic pyramidal neurons (PyNs).
Inquiry
| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Eomestm1.1(cre/ERT2)Zjh
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| Allele Name |
targeted mutation 1.1
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| Allele Attributes |
Recombinase-expressing; Inducible
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| Gene Symbol |
Eomes
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| Gene Name |
eomesodermin
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| Chromosome |
9
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| MGI Accession ID | show more close |
| Strain of Origin |
(C57BL/6 x 129S4/SvJae)F1
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| Molecular Note |
The allele was generated by inserting a 2A-CreER expression cassette in-frame before the STOP codon of the Eomes gene. The targeting vectors generated using BAC clones from the RPCI-23&24 library were electroporated into a 129SVj/B6 hybrid ES cell line (v6.5). The Resulting ES cell clones were used for tetraploid complementation to obtain male heterozygous mice. The neo selection cassette was excised by crossing to FlpE strain mice.
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| HUSBANDRY | |
|---|---|
| Suggested Controls |
B6129SF2/J
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| Breeding Considerations |
Heterozygotes and homozygotes are viable and fertile.
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For Research Use Only.
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