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Mouse Models
Site-specific recombinase (SSR) system is widely used in genetically modification, especially the generation for conditional KO and inducible KO mouse models. For making it more efficient and easier, mouse models with special functions have been generated, such as tissue-specifically expressing Cre, inducible expressing Cre, Split-Cre, floxed (target gene were flanked by loxP sites) mouse, et al.
For assisting our global customers making better breakthrough in their research areas, Creative Biogene offers various of mouse models based on site-specific recombinase systems.
- Floxed Mouse: Floxed mouse models provide a way to study gene function in a controlled and tissue-specific manner, allowing researchers to investigate the roles of specific genes in development, physiology, and disease.
- Reporter Mouse: Reporter mouse models generated with SSR technology offer a means to visualize and study gene expression patterns in a tissue-specific or cell-specific manner. They are invaluable tools in deciphering the intricacies of developmental processes and disease mechanisms.
- Inducible Mouse: Inducible mouse models generated with SSR technology are genetically engineered mouse strains that allow for controlled and temporal regulation of gene expression in specific tissues or cell types.
- Recombinase-expressing Mouse: Recombinase-expressing mouse models are genetically modified mouse models that express Cre recombinase tissue-specifically or temporal-specifically.
If you couldn't find the mouse models you need or you are seeking for other model animals, please check out our gene engineering service or just feel free to contact us and get started with our trustable one-stop service.
Our Mouse Models
| B6.129S4-Grntm1Far/Mmjax (Cat. No.: CEMM-07250441) | Inquiry | |
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These Grnflox mutant mice possess loxP sites flanking the whole coding sequence of the granulin precursor (or progranulin) gene. Progranulin is associated with wound healing, inflammation, embryogenesis, tumor growth and the human neurodegenerative syndrome, frontotemporal lobar dementia (FTLD).
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| STOCK Mir146tm1Mtm/Mmjax (Cat. No.: CEMM-07250454) | Inquiry | |
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These microRNA 146 conditional mutant mice are designed to generate a null allele or a lacZ tagged null allele when combined with Flp or Cre recombinase expressing strains. This mutant mouse strain may be useful in studies of microRNA biology.
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| STOCK Tsc2tm2.1Djk/Mmjax (Cat. No.: CEMM-07250559) | Inquiry | |
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These Tsc2c-del3 mutant mice possess loxP sites flanking exon 3 of the tuberous sclerosis 2 (Tsc2) gene. Tsc2 encodes a tumor growth suppressor associated with tuberous sclerous complex (TSC), an autosomal dominant genetic disease characterized by the development of hamartomas in multiple organ systems.
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| STOCK Gpx4tm1.1Qra/J (Cat. No.: CEMM-07250648) | Inquiry | |
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The Gpx4f allele has loxP sites flanking exons 2- 4 of the glutathione peroxidase 4 gene. Removal of the floxed sequence creates a null allele. Homozygous knockout mice exhibit mitochondrial dysfunction, increased apoptosis and neurodegeneration.
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| STOCK Pax6tm2Pgr/J (Cat. No.: CEMM-07250650) | Inquiry | |
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The Pax6flox allele has loxP sites flanking exon 4-6 of the paired box 6 gene. Removal of the floxed sequence creates a null allele. These mice may be useful in studying the role of PAX6 in the eye, nose, pancreas and central nervous system.
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| B6.Cg-Dpp6tm1.2Dahn/J (Cat. No.: CEMM-07250756) | Inquiry | |
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These conditional knockout mice possess loxP sites flanking exon 2 of dipeptidylpeptidase 6 (Dpp6), a gene involved in the regulation of potassium channels. This strain may be useful in studies of dendritic function and potassium currents.
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| B6.Cg-Tg(CMV-AR*113Q)FMonk/J (Cat. No.: CEMM-07250733) | Inquiry | |
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CMV-stop-AR113Q mice carry a loxP-flanked stop codon upstream of a human androgen receptor gene containing a polyglutamine expansion under the control of a cytomegalovirus promotor. This strain may be useful for generating conditional mutations in studies related to spinobulbar muscular atrophy (Kennedy disease).
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| STOCK Mir7btm1Mtm/Mmjax (Cat. No.: CEMM-07250315) | Inquiry | |
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These microRNA 7b conditional mutant mice are designed to generate a null allele or a lacZ tagged null allele when combined with Flp or Cre recombinase expressing strains. LacZ expression is observed in embryonic brain and spinal cord. This mutant mouse strain may be useful in studies of microRNA biology.
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| STOCK Mirlet7dtm1Mtm/Mmjax (Cat. No.: CEMM-07250316) | Inquiry | |
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These microRNA let7d conditional mutant mice are designed to generate a null allele or a lacZ tagged null allele when combined with Flp or Cre recombinase expressing strains. LacZ expression is observed in embryonic brain and spinal cord. This mutant mouse strain may be useful in studies of microRNA biology.
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| STOCK Mir320tm1Mtm/Mmjax (Cat. No.: CEMM-07250317) | Inquiry | |
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These microRNA 320 conditional mutant mice are designed to generate a null allele or a lacZ tagged null allele when combined with Flp or Cre recombinase expressing strains. This mutant mouse strain may be useful in studies of microRNA biology.
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For Research Use Only.