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B6.129S4-Grntm1Far/Mmjax
Cat. No.: CEMM-07250441
These Grnflox mutant mice possess loxP sites flanking the whole coding sequence of the granulin precursor (or progranulin) gene. Progranulin is associated with wound healing, inflammation, embryogenesis, tumor growth and the human neurodegenerative syndrome, frontotemporal lobar dementia (FTLD).
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| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Grntm1Far
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| Allele Name |
targeted mutation 1
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| Allele Attributes |
Conditional ready (e.g. floxed); No functional change
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| Gene Symbol |
Grn
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| Gene Name |
granulin
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| Chromosome |
11
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| MGI Accession ID | show more close |
| Strain of Origin |
129S4/SvJae
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| Molecular Note |
LoxP sites were inserted flanking exons 2 to 13 and a neo cassette was inserted downstream of the polyadenylation signal via homologous recombination.
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| HUSBANDRY | |
|---|---|
| Suggested Controls |
C57BL/6J
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| Breeding Considerations |
While maintaining a live colony, these mice are bred as homozygotes.
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For Research Use Only.
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