Online Inquiry
STOCK Gpx4tm1.1Qra/J
Cat. No.: CEMM-07250648
Common Name: Gpx4f
The Gpx4f allele has loxP sites flanking exons 2- 4 of the glutathione peroxidase 4 gene. Removal of the floxed sequence creates a null allele. Homozygous knockout mice exhibit mitochondrial dysfunction, increased apoptosis and neurodegeneration.
Inquiry
| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Gpx4tm1.1Qra
show more
close
|
| Allele Name |
targeted mutation 1.1
show more
close
|
| Allele Attributes |
Conditional ready (e.g. floxed); No functional change
show more
close
|
| Gene Symbol |
Gpx4
show more
close
|
| Gene Name |
glutathione peroxidase 4
show more
close
|
| Chromosome |
10
show more
close
|
| MGI Accession ID | show more close |
| Strain of Origin |
129S6/SvEvTac
show more
close
|
| Molecular Note |
A loxP site and FRT flanked neo cassette were inserted upstream of exon 2 and a loxP site was inserted downstream of exon 4 via homologous recombination. Flp mediated recombination removed the neo cassette leaving exons 2 - 4 floxed.
show more
close
|
| HUSBANDRY | |
|---|---|
| Suggested Controls |
C57BL/6J
show more
close
|
| Breeding Considerations |
While maintaining a live colony, these mice are bred as homozygotes.
show more
close
|
| Breeding Strategy |
Homozygote x Homozygote
show more
close
|
For Research Use Only.
Related Products