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STOCK Tsc2tm2.1Djk/Mmjax
Cat. No.: CEMM-07250559
These Tsc2c-del3 mutant mice possess loxP sites flanking exon 3 of the tuberous sclerosis 2 (Tsc2) gene. Tsc2 encodes a tumor growth suppressor associated with tuberous sclerous complex (TSC), an autosomal dominant genetic disease characterized by the development of hamartomas in multiple organ systems.
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| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Tsc2tm2.1Djk
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| Allele Name |
targeted mutation 2.1
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| Allele Attributes |
Conditional ready (e.g. floxed); No functional change
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| Gene Symbol |
Tsc2
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| Gene Name |
tuberous sclerosis 2
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| Chromosome |
17
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| MGI Accession ID | show more close |
| Strain of Origin |
129S4/SvJae
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| Molecular Note |
A loxP and a loxP-neo-loxP cassette flanked exon 3 of Tsc2 which consists of 111 bp, encoding 37 amino acids near the N terminus of the protein (note that in some schemes this is counted as exon 4; however in accordance with human TSC2 gene, it is denoted this as exon 3, labeling a 5' untranslated exon as 1a). The neo cassette was removed in ES cells by transient Cre expression leaving exon 3 floxed.
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| HUSBANDRY | |
|---|---|
| Suggested Controls |
B6129SF2/J
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| Breeding Considerations |
While maintaining a live colony, these mice are bred as homozygotes.
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| Breeding Strategy |
Homozygote x Homozygote
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For Research Use Only.
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