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STOCK Pax6tm2Pgr/J
Cat. No.: CEMM-07250650
Common Name: Pax6flox
The Pax6flox allele has loxP sites flanking exon 4-6 of the paired box 6 gene. Removal of the floxed sequence creates a null allele. These mice may be useful in studying the role of PAX6 in the eye, nose, pancreas and central nervous system.
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| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Pax6tm2Pgr
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| Allele Name |
targeted mutation 2
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| Allele Attributes |
Conditional ready (e.g. floxed); No functional change
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| Gene Symbol |
Pax6
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| Gene Name |
paired box 6
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| Chromosome |
2
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| MGI Accession ID | show more close |
| Strain of Origin |
(129X1/SvJ x 129S1/Sv)F1-Kitl+
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| Molecular Note |
Insertion of loxP sequences flanking the exons encoding the amino terminus of the protein, including the initiator methionine and most of the paired domain. A FRT flanked neomycin cassette in intron 6 was removed via Flp-mediated recomination to Create the final allele. These insertions had no effect on the normal function of the allele.
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| HUSBANDRY | |
|---|---|
| Breeding Considerations |
While maintaining a live colony, these mice are bred as homozygotes.
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For Research Use Only.
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