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B6N.Cg-Pou3f4tm2(cre)Cren/Mmjax
Cat. No.: CEMM-07251046
Pou3f4 knock-in/knock-out mice contain a Cre recombinase that replaces the Pou3f4 (POU domain, class 3, transcription factor 4) coding region. Females homozygous for the mutation and males hemizygous for the X-linked mutation are deaf due to the failure of auditory spiral ganglion neuron radial bundle fasciculation and synapse formation in the cochlea.
Inquiry
| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Pou3f4tm2(cre)Cren
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| Allele Name |
targeted mutation 2
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| Allele Attributes |
Recombinase-expressing; Null/Knockout
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| Gene Symbol |
Pou3f4
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| Gene Name |
POU domain
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| Chromosome |
X
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| MGI Accession ID | show more close |
| Strain of Origin |
(129X1/SvJ x 129S1/Sv)F1-Kitl+
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| Molecular Note |
The Cre recombinase gene replaced the coding region.
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| HUSBANDRY | |
|---|---|
| Suggested Controls |
C57BL/6NJ
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| Breeding Considerations |
When maintaining a live colony, these mice are bred as homozygote female x hemizygous male. Pou3f4 is located on the X chromosome.
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| Breeding Strategy |
Heterozygote x Hemizygote
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For Research Use Only.
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