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STOCK Synprtm1Sud Syngr1tm1Sud Syngr3tm1Sud Syptm1Sud/J
Cat. No.: CEMM-07250107
Common Name: SQI
This compound mutant strain carries targeted knockouts of the Syngr1 (P29; synaptogyrin I) and Syp (P38; synaptophysin I) genes, and floxed conditional mutations of Synpr (SP2; synaptophysin II) and Syngr3 (SG3; synaptogyrin III). This strain may be useful in studies of synaptic plasticity and the role of synaptophysins and synaptogyrins in neurological systems.
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| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Syngr1tm1Sud
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| Allele Name |
targeted mutation 1
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| Allele Attributes |
Null/Knockout
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| Gene Symbol |
Syngr1
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| Gene Name |
synaptogyrin 1
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| Chromosome |
15
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| MGI Accession ID | show more close |
| Strain of Origin |
129S6/SvEvTac
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| Molecular Note |
A neomycin resistance cassette replaced exon II and flanking sequences, which encodes two transmembrane domains of the encoded protein. Western blot analysis on total brain protein confirmed that no detectable encoded protein was present in homozygous mice.
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| HUSBANDRY | |
|---|---|
| Breeding Considerations |
When maintained as a live colony, animals homozygous for all four targeted mutations may be intercrossed.
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For Research Use Only.
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