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B6(Cg)-Cybbtm1.1Abk/J
Cat. No.: CEMM-07250889
Common Name: Cybbfl
NOX2-floxed mice possess loxP sites flanking exon 5 of the Cybb gene. This strain may be useful for generating conditional mutations for sturying chronic granulomatous disease and the role of phagocyte-derived oxidants in inflammation.
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| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Cybbtm1.1Abk
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| Allele Name |
targeted mutation 1.1
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| Allele Attributes |
Conditional ready (e.g. floxed); No functional change
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| Gene Symbol |
Cybb
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| Gene Name |
cytochrome b-245
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| Chromosome |
X
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| MGI Accession ID | show more close |
| Strain of Origin |
C57BL/6NTac
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| Molecular Note |
This targeting vector obtained from the Wellcome Trust Sanger Institute KOMP (Knockout Mouse Project) is used to insert a L1L2_Bact_P cassette containing FRT lacZ-loxP-neo-FRT loxP upstream of exon 5 (at position 9455699 of Chromosome X; Build GRCm38), and a loxP site downstream of exon 5 (at position 9454892). Flp-mediated recombination removed the FRT flanked lacZ/neo cassette.
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| HUSBANDRY | |
|---|---|
| Suggested Controls |
C57BL/6J C57BL/6NJ
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| Breeding Considerations |
The Cybb floxed allele is on the X chromosome. When maintaining a live colony, these mice can be bred as homozygous females and hemizygous males.
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| Breeding Strategy |
Homozygote x Hemizygote
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For Research Use Only.
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