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B6.Cg-Ccl2tm1.1Pame/J
Cat. No.: CEMM-07250319
Common Name: Ccl2-RFPflox
These floxed mutant mice contain loxP sites flanking exons 2-3 of the Ccl2 gene which has been modified with a red fluorescent protein gene (mcherry). Fluorescence is seen in all Ccl2-expressing cells. When these mutant mice are bred to mice that express Cre recombinase, resulting offspring will have exons 2-3, as well as RFP, deleted in the cre-expressing tissue.
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| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Ccl2tm1.1Pame
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| Allele Name |
targeted mutation 1.1 Eric G Pamer
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| Allele Attributes |
Conditional ready (e.g. floxed); No functional change
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| Gene Symbol |
Ccl2
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| Gene Name |
chemokine (C-C motif) ligand 2
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| Chromosome |
11
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| MGI Accession ID | show more close |
| Strain of Origin |
B6(Cg)-Tyrc-2J
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| Molecular Note |
A loxP site was inserted upstream of exon 2. Exon 3 was replaced with a modified exon 3 with an HA-2A cleavable mCherry and 3' loxP site. A floxed neo cassette used for selection purposes was removed by Cre-mediated recombination.
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| HUSBANDRY | |
|---|---|
| Suggested Controls |
C57BL/6J
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| Breeding Considerations |
When maintaining a live colony, homozygous mice may be bred together.
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| Breeding Strategy |
Homozygote x Homozygote
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For Research Use Only.
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