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B6.129S6-Itga8tm1.1Rdav/J
Cat. No.: CEMM-07250301
These f(α8) conditional mutant mice have loxP sites flanking the exons encoding the transmembrane and the cytoplasmic domains of the Itga8 gene (also called integrin alpha 8, alpha8-integrin, or α8-integrin). These f(α8) mutant mice may be useful in generating conditional mutations for studying the role of Itga8 transmembrane cell adhesion receptors in neuronal function in the developing and adult central nervous system, including intracellular signaling, behavior, synaptic plasticity, and memory formation.
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| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Itga8tm1.1Rdav
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| Allele Name |
targeted mutation 1.1
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| Allele Attributes |
Conditional ready (e.g. floxed); No functional change
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| Gene Symbol |
Itga8
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| Gene Name |
integrin alpha 8
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| Chromosome |
2
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| MGI Accession ID | show more close |
| Strain of Origin |
129S6/SvEvTac
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| Molecular Note |
A targeting vector was designed to insert a loxP site just upstream of exon 29, and also insert a loxP-flanked TK-neo cassette about 4kb downstream of the STOP codon in exon 30 of the Itga8 gene (also called integrin alpha 8, alpha8-integrin, or a8-integrin). Cre-mediated recombination removed the TK-neo selection cassette, leaving a single loxP site upstream of exon 29 and a single loxP site downstream of exon 30.
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| HUSBANDRY | |
|---|---|
| Suggested Controls |
C57BL/6J
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| Breeding Considerations |
When maintaining a live colony, homozygous mice may be bred together.
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For Research Use Only.
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