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B6.129-Kdm1atm1.1Sho/J
Cat. No.: CEMM-07250520
Common Name: Lsd1fl
These LSD1fl/fl mutant mice may be useful for studying the epigenetic mechanisms required for proper hematopoietic maturation, as well as the role of LSD1 in activity-evoked transcription of immediate early genes (IEGs) that impact memory formation, emotional behavior and information processing.
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| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Kdm1atm1.1Sho
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| Allele Name |
targeted mutation 1.1
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| Allele Attributes |
Conditional ready (e.g. floxed); No functional change
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| Gene Symbol |
Kdm1a
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| Gene Name |
lysine (K)-specific demethylase 1A
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| Chromosome |
4
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| MGI Accession ID | show more close |
| Strain of Origin |
129S1/Sv-Oca2+ Tyr+ Kitl+
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| Molecular Note |
A targeting vector was designed to insert a single loxP site followed by a FRT flanked neomycin resistance (neo) cassette upstream of exon 5, and a second loxP site downstream of exon 6. Exons 5 and 6 encode a flavin adenine dinucleotide binding site and the N-terminal portion of the amine oxidase domain, both required for enzymatic activity. FLPe-mediated recombination removed the selection cassette.
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| HUSBANDRY | |
|---|---|
| Suggested Controls |
C57BL/6J C57BL/6NJ
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| Breeding Considerations |
When maintaining a live colony, homozygous mice may be bred together.
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For Research Use Only.
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