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B6;129-Igs1tm4(CAG-Bgeo, -Vangl2)Nat/J
Cat. No.: CEMM-07250391
This Ubb (ubiquitin B) knock-in strain gives consitutive expression of nuclear-localized beta-galactosidase/neomycin resistance protein reporter (NLS-beta-geo) in the absence of cre-mediated recombination. Following cre-mediated recombination, Vangl2 (vang-like 2 (van gogh, Drosophila)) protein with 3xHA (hemagglutinin) tag is expressed.
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| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Igs1tm4(CAG-Bgeo,-Vangl2)Nat
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| Allele Name |
targeted mutation 4
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| Allele Attributes |
Conditional ready (e.g. floxed); Reporter; Inserted expressed sequence; No functional change
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| Gene Symbol |
Igs1
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| Gene Name |
intergenic site 1
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| Chromosome |
11
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| Expressed Genes |
Bgeo, fusion of beta-galactosidase and neomycin phosphotransferase genes, E. coli
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| MGI Accession ID | show more close |
| Site of Expression |
Consitutive expression of the nuclear-localized beta-galactosidase/neomycin resistance protein reporter (NLS-beta-geo).
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| Strain of Origin |
129
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| Molecular Note |
The following elements were inserted, in order, 2 kb 5' of the gene by targetedrecombination: CMV enhancer/beta-actin promoter (CAG), loxP site, beta-geo cassette, 3 transcription stop sites, a loxP site, Vangl2 with 3 HA-tags, and rabbit beta-globin 3' UTR.
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| HUSBANDRY | |
|---|---|
| Breeding Considerations |
Heterozygotes are viable and fertile, but homozygotes are unhealthy.
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For Research Use Only.
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