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B6.129-Ank3tm2.1Bnt/J
Cat. No.: CEMM-07250758
Common Name: Ank3 flox
Exons 22 and 23 of the mouse Ank3 (ankyrin 3, epithelial) gene are flanked by loxP sites in this conditional mutant strain. Cre-mediated excision of the floxed region results in a specific knock-out of the 190-, 270-, and 480-kDa isoforms of the gene that are required for membrane protein interactions. This strain may be useful in studies of cell membrane formation and maintenance.
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| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Ank3tm2.1Bnt
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| Allele Name |
targeted mutation 2.1
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| Allele Attributes |
Conditional ready (e.g. floxed); No functional change
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| Gene Symbol |
Ank3
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| Gene Name |
ankyrin 3
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| Chromosome |
10
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| MGI Accession ID | show more close |
| Strain of Origin |
129X1/SvJ
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| Molecular Note |
A loxP site was inserted upstream of exon 22. An FRT flanked neomycin resistance cassette with a 3' loxp site was inserted downstream of exon 23. Flp-mediated recombination removed the neomycin resistance cassette and left exons 22 and 23 floxed.
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| HUSBANDRY | |
|---|---|
| Suggested Controls |
C57BL/6J
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| Breeding Considerations |
Heterozygous and homozygous floxed mice are viable and fertile.
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| Breeding Strategy |
Heterozygote x Heterozygote
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For Research Use Only.
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