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STOCK Hdctm1.1(icre)Wwis/J
Cat. No.: CEMM-07250440
The HDC-Cre mice express a codon optimized Cre recombinase (iCre) from the histidine decarboxylase (Hdc) promoter/enhancer elements. These mice may be useful for studying the role of histaminergic neurons.
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| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Hdctm1.1(icre)Wwis
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| Allele Name |
targeted mutation 1.1
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| Allele Attributes |
Recombinase-expressing
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| Gene Symbol |
Hdc
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| Gene Name |
histidine decarboxylase
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| Chromosome |
2
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| MGI Accession ID | show more close |
| Site of Expression |
When Hdc is induced, Cre recombinase is expressed in tuberomammillary nucleus of the hypothalamus as well as other areas of the brain, mast cells, gastric mucosa, and fetal liver.
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| Strain of Origin |
(129X1/SvJ x 129S1/Sv)F1-Kitl+
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| Molecular Note |
A targeting vector was generated to insert an improved IRES2i site, a humanized Cre open reading frame and an FRT flanked neo selection cassette into exon 12 of histidine decarboxylase between the stop codon and polyadenylation sequence, by homologous recombination in ES cells. Chimeras were produced by ES cell injection into C57BL/6J blastocysts. The resulting line was bred with Flp deleter mice to remove the neo cassette.
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| HUSBANDRY | |
|---|---|
| Breeding Considerations |
The donating investigator has not attempted to generate homozygous mice to date. When maintaining a live colony, heterozygous mice may be bred to wildtype (non-carrier) mice from the colony or with C57BL/6J inbred mice.
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For Research Use Only.
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