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B6;129-Ncstntm1Sud/J
Cat. No.: CEMM-07250111
Common Name: NCF
Floxed homozygous mice express intact nicastrin gene. They are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. When these mutant mice are bred to mice that express Cre recombinase, resulting offspring will have exon 3 deleted in the cre-expressing tissue(s). These mice are useful to study the role of g-secretase in various tissues in combination with tissue specific cre lines.
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| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Ncstntm1Sud
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| Allele Name |
targeted mutation 1
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| Allele Attributes |
Conditional ready (e.g. floxed); No functional change
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| Gene Symbol |
Ncstn
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| Gene Name |
nicastrin
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| Chromosome |
1
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| MGI Accession ID | show more close |
| Strain of Origin |
(129X1/SvJ x 129S1/Sv)F1-Kitl+
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| Molecular Note |
A neomycin resistance cassette, flanked by loxP and Frt sites was introduced to intron 2 and an additional loxP site was placed in intron 3. Floxed homozygous mice express intact nicastrin gene.
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For Research Use Only.
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