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STOCK Tg(Nes-cre)2Wme/J
Cat. No.: CEMM-07250002
Common Name: bal2
These bal2 mice express a transgene containing Cre recombinase under the control of the rat nestin promoter.
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| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Tg(Nes-cre)2Wme
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| Allele Name |
transgene insertion 2
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| Allele Attributes |
Recombinase-expressing
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| Gene Symbol |
Tg(Nes-cre)2Wme
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| Gene Name |
transgene insertion 2
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| Chromosome |
UN
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| Expressed Genes |
Cre, Cre recombinase, bacteriophage P1
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| MGI Accession ID | show more close |
| Site of Expression |
Induces variable mosaicism/partial deletion of loxP-flanked alleles before embryonic day 10.5 and in all adult organs (including germline), producing mosaic mice consisting of cells that are either wildtype or mutant for the gene of interest, more variable mosaicism than the "balancer 1" line
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| Strain of Origin |
(C57BL/6 x CBA)F2
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| Molecular Note |
The transgenic construct contained a nestin promoter followed by Cre recombinase sequence adjoined to a nuclear localization signal. Intron 2 of the nestin gene was included downstream of a polyadenylation signal. While the endogenous nestin promoter is CNS-specific, Southern blot analysis showed the ubiquitous expression of Cre in transgenic mice. Variable mosaicism/partial deletion of the loxP-flanked allele occurs, and it may be detected in all adult organs including germ line cells.
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| HUSBANDRY | |
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| Breeding Considerations |
This strain is currently on a mixed C57BL/6,129, and CBA background. The expected coat color from breeding is black.
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For Research Use Only.
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