Products

Online Inquiry

STOCK Hand2tm1.1Majh/AbfiJ

Cat. No.: CEMM-07250641

Common Name: Hand2 floxed (Hand2loxp; Hand2ploxp; Hand2fl; Hand2flox)
The Hand2fl allele has loxP sites flanking exon 1 (PGK-neo removed) of the Hand2 gene. These floxed mice are used to generate global or tissue-specific Hand2 deletion mice, which allow studies of this transcription factor in sympathetic nervous system morphogenesis and cell type-specific gene expression in sympathetic, enteric and adrenal chromaffin cells, cardiac morphogenesis and limb bud / branchial arch development. The absence of Hand2 expression may also be a useful biomarker for atypical hyperplasia, endometrioid carcinoma and epigenetic silencing.
Inquiry
Status Live Mouse
Frozen Embryo
Age 4 weeks
12 weeks
Customized Age
Sex Male
Female
GENETICS
Allele Symbol
Hand2tm1.1Majh
show more close
Allele Name
targeted mutation 1.1
show more close
Allele Attributes
Conditional ready (e.g. floxed); No functional change
show more close
Gene Symbol
Hand2
show more close
Gene Name
heart and neural crest derivatives expressed 2
show more close
Chromosome
8
show more close
MGI Accession ID
3803647
show more close
Strain of Origin
129S1/SvImJ
show more close
Molecular Note
A loxP site was inserted upstream of exon 1 and a floxed neo cassette was inserted downstream of exon 1. Germ line, Cre-mediated recombination was used to remove the neo cassette leaving exon 1 floxed.
show more close
HUSBANDRY
Suggested Controls
B6129SF2/J
show more close
Breeding Considerations
When maintaining a live colony, heterozygous mice may be bred together, to wildtype mice from the colony or to C57BL/6J inbred mice. Alternatively, homozygous mice may be bred together.
show more close
Breeding Strategy
Heterozygote x Heterozygote
show more close
For Research Use Only.
Related Products