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STOCK Isl1tm2Sev/J
Cat. No.: CEMM-07250669
Common Name: Isl1fl
The Isl1fl floxed allele has loxP sites flanking the homeodomain (exon 4) of the LIM-homeodomain factor Islet1 gene. Homozygous removal of the floxed sequences results in a phenotype consistent with complete loss of Isl1 function. These mice may be useful in studying cardiac development and early development of motor neurons/sensory neurogenesis.
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| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Isl1tm2Sev
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| Allele Name |
targeted mutation 2
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| Allele Attributes |
Conditional ready (e.g. floxed); No functional change
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| Gene Symbol |
Isl1
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| Gene Name |
ISL1 transcription factor
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| Chromosome |
13
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| MGI Accession ID | show more close |
| Strain of Origin |
(129X1/SvJ x 129S1/Sv)F1-Kitl+
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| Molecular Note |
Exon 4, which encodes the homeodomain of the protein product, was floxed by the insertion of a loxP site on one end and a loxP site and FRT flanked neo cassette on the other end. After germline integration, the FRT flanked neo cassette was removed from Isl1tm4Sev by crossing with FLPe transgenic strain.
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| HUSBANDRY | |
|---|---|
| Suggested Controls |
Wild-type from the colony
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| Breeding Considerations |
When maintaining a live colony, heterozygous mice may be bred together, to wildtype mice from the colony or to C57BL/6J inbred mice. Alternatively, homozygous mice may be bred together.
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For Research Use Only.
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