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B6;CBA-Tg(Tbx21-cre)1Dlc/J
Cat. No.: CEMM-07250541
Common Name: Tbet-cre
These transgenic mice express Cre recombinase from the mouse Tbx21 (T-box 21; also called Tbet) promoter in mitral cells of the main and accessory olfactory bulbs.
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| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Tg(Tbx21-cre)1Dlc
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| Allele Name |
transgene insertion 1
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| Allele Attributes |
Recombinase-expressing
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| Gene Symbol |
Tg(Tbx21-cre)1Dlc
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| Gene Name |
transgene insertion 1
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| Chromosome |
UN
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| Expressed Genes |
Cre, Cre recombinase, bacteriophage P1
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| MGI Accession ID | show more close |
| Site of Expression |
The T-box 21 (Tbx21) promoter drives the expression of Cre recombinase in mitral cells of the main and accessory olfactory bulbs.
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| Strain of Origin |
C57BL/6 x CBA
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| Molecular Note |
Cre cDNA was inserted at the start ATG of the Tbx21 gene in a BAC (RP23-237M14). The recombined BAC was linearized and injected into B6/CBA oocytes. 14 animals were generated and one was determined to be positive for the Tbx21-Cre transgene. The single founder line was analyzed by immunohistochemistry for Cre protein. Strong expression was detected and reporter crosses displayed recombination in the mitral and external tufted layers of the main and accessory olfactory bulbs, with no other brain tissues showing recombination. Activity was also observed in the thymus, a known site of Tbx21 expression.
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| HUSBANDRY | |
|---|---|
| Suggested Controls |
Noncarrier
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| Breeding Considerations |
Homozygous and hemizygous mice are viable and fertile.
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| Breeding Strategy |
Noncarrier x Hemizygote; Hemizygote x Noncarrier
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For Research Use Only.
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