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STOCK Rorbtm1.1(cre/ERT2)Ddg/J
Cat. No.: CEMM-07250790
Common Name: RorβCreER
These knock-in/knock-out targeted mutant mice express tamoxifen-inducible cre-ERT2 fusion protein from the mouse Rorb promoter in the spinal cord dorsal horn and barrel cortex.
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| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Rorbtm1.1(cre/ERT2)Ddg
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| Allele Name |
targeted mutation 1.1
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| Allele Attributes |
Recombinase-expressing; Inducible
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| Gene Symbol |
Rorb
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| Gene Name |
RAR-related orphan receptor beta
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| Chromosome |
19
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| Expressed Genes |
cre/ERT2, Cre recombinase and estrogen receptor 1 (human) fusion gene
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| MGI Accession ID | show more close |
| Site of Expression |
When bred with mice containing a loxP-flanked sequence of interest, Tamoxifen-inducible, Cre-mediated recombination will result in tissue-specific deletion of the floxed region in the spinal cord dorsal horn and barrel cortex.
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| Strain of Origin |
129S6/SvEvTac
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| Molecular Note |
A Cre recombinase-estrogen receptor T2 (CreERT2) fusion-FRT Neomycin-FRT loxP cassette was introduced into the first coding ATG, replacing the last 4 bp of the exon 1. Homologous recombination was achieved in 129S6/SvEvTac-derived embryonic stem cells and resultant chimeric mice were crossed with Flp mice to excise the neomycin cassette,
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| HUSBANDRY | |
|---|---|
| Suggested Controls |
Wild-type from the colony
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| Breeding Considerations |
Heterozygotes are viable and fertile. Homozygous males have limited fertility (they have a low sperm count and stop breeding early).
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| Breeding Strategy |
Heterozygote x Heterozygote
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For Research Use Only.
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