STOCK Tg(Tph2-icre/ERT2)6Gloss/J

Cat. No.: CEMM-07250313

Common Name: TPH2-iCreER

These TPH2-iCreER transgenic mice express a tamoxifen-inducible Cre recombinase under the control of the mouse Tph2 promoter and may be useful for generating conditional mutations for studying gain or loss of function and/or fate mapping of Tph2 expressing neurons in the raphe nucleus.

Inquiry

Status	Live Mouse Frozen Embryo
Age	4 weeks 12 weeks Customized Age
Sex	Male Female

GENETICS
Allele Symbol	Tg(Tph2-icre/ERT2)6Gloss show more close
Allele Name	transgene insertion 6 show more close
Allele Attributes	Recombinase-expressing; Inducible show more close
Gene Symbol	Tg(Tph2-icre/ERT2)6Gloss show more close
Gene Name	transgene insertion 6 show more close
Chromosome	UN show more close
Expressed Genes	Cre, Cre recombinase, bacteriophage P1; ESR1, estrogen receptor 1, human show more close
MGI Accession ID	5049908 show more close
Site of Expression	Tamoxifen administration induces Cre recombination in Tph2-expressing neurons in the raphe nucleus. show more close
Strain of Origin	C57BL/6NTac show more close
Molecular Note	The mouse bacterial artificial chromosome (BAC) RP23-151J17 containing Tph2, solute carrier family 6 (neurotransmitter transporter, dopamine), member 3, gene, was modified by insertion of sequence encoding iCreER at the Tph2 translation initiation ATG, and addition of a Kozak sequence upstream of the ATG. This BAC also contains the following genes: Tbc1d15, (TBC1 domain family, member 15), and AK048828. The modified BAC was used to generate the TPH2-iCreER transgene, which was microinjected into C57BL/6NTac fertilized eggs. Founder line 6 was subsequently established. show more close

HUSBANDRY
Suggested Controls	C57BL/6NJ show more close
Breeding Considerations	When maintaining a live colony, these mice can be bred as homozygotes. show more close

For Research Use Only.