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STOCK Optntm1.1Jda/J
Cat. No.: CEMM-07250752
Common Name: Optn floxed
These floxed mutant mice possess loxP sites flanking exon 12 of the Optn gene. This strain may be useful for generating conditional mutations in applications related to the study of ubiquitination in neurodegenerative diseases.
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| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Optntm1.1Jda
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| Allele Name |
targeted mutation 1.1
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| Allele Attributes |
Conditional ready (e.g. floxed); No functional change
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| Gene Symbol |
Optn
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| Gene Name |
optineurin
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| Chromosome |
2
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| MGI Accession ID | show more close |
| Strain of Origin |
(C57BL/6J x 129S4/SvJae)F1
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| Molecular Note |
A loxP site was inserted upstream of exon 12. An FRT and loxP-flanked neomycin resistance cassette was inserted downstream of exon 12. Flp-mediated recombination removed the selection cassette and left exon 12 floxed.
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| HUSBANDRY | |
|---|---|
| Suggested Controls |
C57BL/6J
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| Breeding Considerations |
When maintaining a live colony, these mice can be bred as homozygotes.
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For Research Use Only.
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