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STOCK Ntrk3tm3.1(cre/ERT2)Ddg/J
Cat. No.: CEMM-07250791
Common Name: TrkCCreER
These targeted knock-in/knock-out mutant mice express tamoxifen-inducible cre-ERT2 fusion protein from the mouse Ntrk3/TrkC promoter. Expression occurs in Ntrk3-expressing cells, including subsets of dorsal root ganglia neurons and the spinal cord.
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| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Ntrk3tm3.1(cre/ERT2)Ddg
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| Allele Name |
targeted mutation 3.1
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| Allele Attributes |
Recombinase-expressing; Inducible
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| Gene Symbol |
Ntrk3
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| Gene Name |
neurotrophic tyrosine kinase
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| Chromosome |
7
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| Expressed Genes |
cre/ERT2, Cre recombinase and estrogen receptor 1 (human) fusion gene
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| MGI Accession ID | show more close |
| Site of Expression |
Cre-ERT2 fusion protein is expressed in Ntrk3-expressing cells, including subsets of dorsal root ganglia neurons and the spinal cord.
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| Strain of Origin |
129S6/SvEvTac
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| Molecular Note |
An indicible Cre recombinase gene (Cre/ERT2) and an FRT flanked neomycin resistance cassette were inserted at the translation initiation site replacing the coding sequence in exon 1. Flp-mediated recombination removed the selection cassette.
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| HUSBANDRY | |
|---|---|
| Suggested Controls |
Wild-type from the colony
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| Breeding Considerations |
Heterozygous mice are viable and fertile. Mice homozygous for this presumptive knock-out allele are not viable.
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| Breeding Strategy |
Wild-type x Heterozygote; Heterozygote x Wild-type
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For Research Use Only.
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