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B6(Cg)-Gt(ROSA)26Sortm1.1(DUX4*)Plj/J
Cat. No.: CEMM-07250691
Common Name: Dux4-fl
FLExDUX4 mice conditionally express human DUX4 following Cre-mediated recombination. This strain may be useful for studying facioscapulohumeral muscular dystrophy (FSHD).This strain is currently unavailable due to replenishing of cryopreserved stocks. Interested customers can register interest.
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| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Gt(ROSA)26Sortm1.1(DUX4*)Plj
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| Allele Name |
targeted mutation 1.1
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| Allele Attributes |
Conditional ready (e.g. floxed); Inserted expressed sequence; Humanized sequence
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| Gene Symbol |
Gt(ROSA)26Sor
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| Gene Name |
gene trap ROSA 26
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| Chromosome |
6
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| Expressed Genes |
DUX4, double homeobox 4, human
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| MGI Accession ID | show more close |
| Strain of Origin |
C57BL/6
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| Molecular Note |
The targeting vector was designed with (from 5 to 3) a loxP site, an FRT flanked neomycin resistance gene, a lox511 site, an inverted human double homeobox 4 (DUX4) gene with a polyadenylation sequence, and another loxP site and lox511 site, both in opposite orientation to the 5 sites. The DUX4 gene contains 4 silent point mutations in exon 1 that prevent alternative splicing of a truncated isoform, DUX4-s, while maintaining the DUX4-fl ORF. This entire construct was inserted between exons 1 and 2 of the Gt(ROSA)26Sor locus. Flp-mediated recombination removed the FRT flanked neo cassette.
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| HUSBANDRY | |
|---|---|
| Suggested Controls |
C57BL/6J
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| Breeding Considerations |
When maintaining a live colony, homozygous mice may be bred together.
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| Breeding Strategy |
Homozygote x Homozygote
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For Research Use Only.
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