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STOCK F3tm1Nmk/J
Cat. No.: CEMM-07250695
Common Name: TFflox
The TFflox floxed allele has loxP sites flanking exon 1 of the coagulation factor III gene (F3; tissue factor [TF], thromboplastin or CD142). Removal of the floxed sequence creates a null allele. These mice may be useful in studying deficiency of the primary activator of the blood coagulation cascade.
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| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
F3tm1Nmk
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| Allele Name |
targeted mutation 1
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| Allele Attributes |
Conditional ready (e.g. floxed); No functional change
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| Gene Symbol |
F3
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| Gene Name |
coagulation factor III
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| Chromosome |
3
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| MGI Accession ID | show more close |
| Strain of Origin |
129S6/SvEvTac
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| Molecular Note |
A loxP site was inserted upstream of exon 1 and an FRT flanked neo cassette with a 5' loxP site was inserted downstream of exon 1. Germ line, flp-mediated reombination was used to remove the neo cassette leaving exon 1 floxed.
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| HUSBANDRY | |
|---|---|
| Suggested Controls |
C57BL/6J
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| Breeding Considerations |
When maintaining a live colony, heterozygous mice may be bred together, to wildtype mice from the colony or to C57BL/6J inbred mice. Alternatively, homozygous mice may be bred together.
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For Research Use Only.
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