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Mouse Models
Site-specific recombinase (SSR) system is widely used in genetically modification, especially the generation for conditional KO and inducible KO mouse models. For making it more efficient and easier, mouse models with special functions have been generated, such as tissue-specifically expressing Cre, inducible expressing Cre, Split-Cre, floxed (target gene were flanked by loxP sites) mouse, et al.
For assisting our global customers making better breakthrough in their research areas, Creative Biogene offers various of mouse models based on site-specific recombinase systems.
- Floxed Mouse: Floxed mouse models provide a way to study gene function in a controlled and tissue-specific manner, allowing researchers to investigate the roles of specific genes in development, physiology, and disease.
- Reporter Mouse: Reporter mouse models generated with SSR technology offer a means to visualize and study gene expression patterns in a tissue-specific or cell-specific manner. They are invaluable tools in deciphering the intricacies of developmental processes and disease mechanisms.
- Inducible Mouse: Inducible mouse models generated with SSR technology are genetically engineered mouse strains that allow for controlled and temporal regulation of gene expression in specific tissues or cell types.
- Recombinase-expressing Mouse: Recombinase-expressing mouse models are genetically modified mouse models that express Cre recombinase tissue-specifically or temporal-specifically.
If you couldn't find the mouse models you need or you are seeking for other model animals, please check out our gene engineering service or just feel free to contact us and get started with our trustable one-stop service.
Our Mouse Models
| B6.Cg-Nfkb2tm1Ukl/J (Cat. No.: CEMM-07250694) | Inquiry | |
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These floxed mutant mice possess loxP sites flanking exons 1 and 2 of the Nfkb2 gene. This strain may be useful for generating conditional mutations in applications related to the study of the B-cell nuclear factor-ΚB (NF-ΚB) pathway. Cre-mediated recombination also results in expression of GFP (Green Fluorescent Protein) which can be used to trace Nfkb2 ablation.
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| STOCK Becn1tm1.1Yue/J (Cat. No.: CEMM-07250699) | Inquiry | |
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These floxed mutant mice possess loxP sites flanking exon 2 of the Becn1 gene. This strain may be useful for generating conditional mutations in applications related to the regulation of autophagy, tumorigenesis, tumor progression and neurodegeneration.
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| B6;129-Dvl2tm1.1Wds/J (Cat. No.: CEMM-07250713) | Inquiry | |
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These floxed mutant mice possess loxP sites flanking exons 2-14 of the Dvl2 gene. This strain may be useful for generating conditional mutations in studies of neurodevelopment and planar cell polarity.
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| B6.129S(Cg)-Khdrbs2tm1.1Schei/J (Cat. No.: CEMM-07250719) | Inquiry | |
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These Slm1 floxed mutant mice possess loxP sites flanking exon 2 of the Khdrbs2 gene. This strain may be useful for generating conditional mutations in applications related to the regulation of alternative splicing.
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| B6.129S6(Cg)-Khdrbs3tm1.1Schei/J (Cat. No.: CEMM-07250720) | Inquiry | |
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These Slm2flox mutant mice possess loxP sites flanking exon 2 of the Khdrbs3 gene. This strain may be useful for generating conditional mutations in applications related to the regulation of alternative splicing and nonsense-mediated mRNA decay.
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| B6;129S4-Hmga2tm1.1Mmw/J (Cat. No.: CEMM-07250737) | Inquiry | |
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These Hmga2CK mice possess pairs of variant loxP sites on either side of exon 2 and a SA-GFP-SD cassette (in reverse orientation) in intron 2 of the Hmga2 gene. Cre-recombination puts GFP under the control of all of the endogenous regulatory elements of endogenous Hmga2 (while also creating a null allele). Applications may include growth, development, transcriptional regulation and cancer metastasis.
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| STOCK Trpm2tm1.1(icre)Jsmn/J (Cat. No.: CEMM-07250745) | Inquiry | |
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Trpm2-Cre knock-in mice have the endogenous Trpm2 locus directing expression of Cre recombinase to 97% of TRPM2-expressing neurons in the preoptic area of the hypothalamus. These mice are useful in studies of the fever response and thermoregulation.
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| STOCK Optntm1.1Jda/J (Cat. No.: CEMM-07250752) | Inquiry | |
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These floxed mutant mice possess loxP sites flanking exon 12 of the Optn gene. This strain may be useful for generating conditional mutations in applications related to the study of ubiquitination in neurodegenerative diseases.
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| FVB.Cg-Adam22tm1Mejr/MpanJ (Cat. No.: CEMM-07250755) | Inquiry | |
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These floxed mutant mice possess loxP sites flanking exon 1 of the Adam22 gene. This strain may be useful for generating conditional mutations in applications related to neurogenesis, myelin formation, and synaptic function.
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| B6;129S6-Sestd1tm1Bnrc/J (Cat. No.: CEMM-07250802) | Inquiry | |
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These floxed mutant mice possess loxP sites flanking exons 4 and 5 of the Sestd1 gene. This strain may be useful for generating conditional mutations in applications related to planar cell polarity during embryonic development.
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For Research Use Only.