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B6;129S4-Hmga2tm1.1Mmw/J
Cat. No.: CEMM-07250737
These Hmga2CK mice possess pairs of variant loxP sites on either side of exon 2 and a SA-GFP-SD cassette (in reverse orientation) in intron 2 of the Hmga2 gene. Cre-recombination puts GFP under the control of all of the endogenous regulatory elements of endogenous Hmga2 (while also creating a null allele). Applications may include growth, development, transcriptional regulation and cancer metastasis.
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| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Hmga2tm1.1Mmw
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| Allele Name |
targeted mutation 1.1
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| Allele Attributes |
Conditional ready (e.g. floxed)
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| Gene Symbol |
Hmga2
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| Gene Name |
high mobility group AT-hook 2
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| Chromosome |
10
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| MGI Accession ID | show more close |
| Site of Expression |
When these mutant mice are bred to mice that express Cre recombinase, the resulting offspring will express GFP in the Cre-expressing tissues
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| Strain of Origin |
(C57BL/6 x 129S4/SvJae)F1
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| Molecular Note |
An FRT flanked neomycin resistance cassette with 3' loxP2272 and loxP5171 site was inserted upstream of exon 2. An inverted EGFP expression cassette with 3' loxP2272 and loxP5171 sites was inserted downstream of exon 2 without affecting Mir763. Flp-mediated recombination removed the selection cassette.
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| HUSBANDRY | |
|---|---|
| Suggested Controls |
B6129SF2/J
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| Breeding Considerations |
When maintaining a live colony, these mice can be bred as homozygotes.
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For Research Use Only.
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