Products

Online Inquiry

B6.Cg-Nfkb2tm1Ukl/J

Cat. No.: CEMM-07250694

Common Name: Nfkb2 flox
These floxed mutant mice possess loxP sites flanking exons 1 and 2 of the Nfkb2 gene. This strain may be useful for generating conditional mutations in applications related to the study of the B-cell nuclear factor-ΚB (NF-ΚB) pathway. Cre-mediated recombination also results in expression of GFP (Green Fluorescent Protein) which can be used to trace Nfkb2 ablation.
Inquiry
Status Live Mouse
Frozen Embryo
Age 4 weeks
12 weeks
Customized Age
Sex Male
Female
GENETICS
Allele Symbol
Nfkb2tm1Ukl
show more close
Allele Name
targeted mutation 1
show more close
Allele Attributes
Conditional ready (e.g. floxed); Reporter; No functional change
show more close
Gene Symbol
Nfkb2
show more close
Gene Name
nuclear factor of kappa light polypeptide gene enhancer in B cells 2
show more close
Chromosome
19
show more close
Expressed Genes
GFP, Green Fluorescent Protein
show more close
MGI Accession ID
5788158
show more close
Site of Expression
When bred to mice that express Cre recombinase, GFP is expressed in Cre-expressing tissues.
show more close
Strain of Origin
(C57BL/6J x 129S6/SvEvTac)F1
show more close
Molecular Note
Sequence encoding a promoterless eGFP minigene, a loxP site and the PGKneo cassette is inserted upstream of exon 1 of the targeted gene, and another loxP site followed by the PGK promoter is inserted downstream of exon 2. The translation start site is in exon 2. The entire targeted region is flanked by FRT sites. Recombination using Cre recombinase will remove the exons while allowing EGFP expression or FLP-mediated recombination will remove both the exons and the EGFP.
show more close
HUSBANDRY
Suggested Controls
C57BL/6J
show more close
Breeding Considerations
When maintaining a live colony, these mice can be bred as homozygotes.
show more close
Breeding Strategy
Heterozygote x Heterozygote
show more close
For Research Use Only.
Related Products