Online Inquiry
STOCK Trpm2tm1.1(icre)Jsmn/J
Cat. No.: CEMM-07250745
Trpm2-Cre knock-in mice have the endogenous Trpm2 locus directing expression of Cre recombinase to 97% of TRPM2-expressing neurons in the preoptic area of the hypothalamus. These mice are useful in studies of the fever response and thermoregulation.
Inquiry
| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Trpm2tm1.1(icre)Jsmn
show more
close
|
| Allele Name |
targeted mutation 1.1
show more
close
|
| Allele Attributes |
Recombinase-expressing
show more
close
|
| Gene Symbol |
Trpm2
show more
close
|
| Gene Name |
transient receptor potential cation channel
show more
close
|
| Chromosome |
10
show more
close
|
| Expressed Genes |
Cre, Cre recombinase, bacteriophage P1
show more
close
|
| MGI Accession ID | show more close |
| Site of Expression |
Cre recombinase activity is expressed in Trpm2 expressing neurons in the preoptic area of the hypothalamus, with weaker activity detected in the cortex.
show more
close
|
| Strain of Origin |
(C57BL/6 x 129P2/OlaHsd)F1
show more
close
|
| Molecular Note |
A targeting vector containing a T2A viral 2A peptide, iCre recombinase sequence, T2A viral 2A peptide, multicistronic element (derived from insect Thosea asigna virus 2A), and FRT site flanked NEO cassette was inserted upstream of the Trpm2 gene stop codon. The resulting chimeric animals were crossed to FLPeR recombinase (Gt(ROSA)26Sor) expressing females to excise the FRT site flanked NEO cassette.
show more
close
|
| HUSBANDRY | |
|---|---|
| Suggested Controls |
C57BL/6J
show more
close
|
| Breeding Considerations |
When maintaining a live colony, these mice can be bred as homozygotes.
show more
close
|
| Breeding Strategy |
Heterozygote x Heterozygote
show more
close
|
For Research Use Only.
Related Products