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Mouse Models
Site-specific recombinase (SSR) system is widely used in genetically modification, especially the generation for conditional KO and inducible KO mouse models. For making it more efficient and easier, mouse models with special functions have been generated, such as tissue-specifically expressing Cre, inducible expressing Cre, Split-Cre, floxed (target gene were flanked by loxP sites) mouse, et al.
For assisting our global customers making better breakthrough in their research areas, Creative Biogene offers various of mouse models based on site-specific recombinase systems.
- Floxed Mouse: Floxed mouse models provide a way to study gene function in a controlled and tissue-specific manner, allowing researchers to investigate the roles of specific genes in development, physiology, and disease.
- Reporter Mouse: Reporter mouse models generated with SSR technology offer a means to visualize and study gene expression patterns in a tissue-specific or cell-specific manner. They are invaluable tools in deciphering the intricacies of developmental processes and disease mechanisms.
- Inducible Mouse: Inducible mouse models generated with SSR technology are genetically engineered mouse strains that allow for controlled and temporal regulation of gene expression in specific tissues or cell types.
- Recombinase-expressing Mouse: Recombinase-expressing mouse models are genetically modified mouse models that express Cre recombinase tissue-specifically or temporal-specifically.
If you couldn't find the mouse models you need or you are seeking for other model animals, please check out our gene engineering service or just feel free to contact us and get started with our trustable one-stop service.
Our Mouse Models
| B6;129-Anks1btm1Bnaj/J (Cat. No.: CEMM-07251008) | Inquiry | |
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AIDA-1fl mice have exon 20 of the ankyrin repeat and sterile alpha motif domain containing 1B (Anks1b) gene floxed. These mice may be useful when studying neurodevelopmental disorders.
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| C57BL/6-Tg(CAG-EGFP, -birA*)1Fink/J (Cat. No.: CEMM-07251048) | Inquiry | |
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ER-BioIDHA (Secretome) knock-in mice have a CAG promoter controlling the Cre-inducible expression of a ER-BioID2HA fusion protein. Cre-mediated recombination results in the secretion of biotinylated proteins in a tissue-specific fashion when given exogenous biotin in their diet. These mice provide a genetic platform to delineate tissue-specific in vivo secretion.
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| B6.129(Cg)-Oprl1tm1.1Mrbr/J (Cat. No.: CEMM-07251055) | Inquiry | |
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NOPRloxP/YFP conditional mutant mice possess loxP sites flanking exons 3-4 and an EYFP reporter (that expresses prior to cre recombination) in the Oprl1 (opioid receptor-like 1) gene and may be useful in generating conditional mutations to study reward motivation.
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| B6(SJL)-Gt(ROSA)26Sortm1.1(CAG-iRFP*/mScarlet-I*/mTq2*/mVenus*)Rva/J (Cat. No.: CEMM-07251084) | Inquiry | |
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These PRimary colours In the MEmbrane (PRIME) mice have a CAG promoter followed by three pairs of heterospecific lox sites (loxP, lox2272 and loxN), and the PRIME construct, all targeted into the Gt(ROSA)26Sor locus (RosaPRIME). PRIME contains four fluorescent proteins and functions as a Cre recombinase-inducible reporter of either a nuclear near-infrared fluorescent protein (3xNLS-iRFP670) or one of three membrane-bound fluorescent proteins from a single genomic locus.
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| C57BL/6-Pgbd5tm1.1Aken/J (Cat. No.: CEMM-07251115) | Inquiry | |
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Pgbd5-floxed mice possess loxP sites flanking exon 4 of the piggyBac transposable element derived 5 (Pgbd5) gene. These mice may be useful for studying the role of Pgbd5 in neuronal development and plasticity as well as genomic rearrangements and instability in various cancers.
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| B6.Cg-Rgs2em1Jgro/J (Cat. No.: CEMM-07251121) | Inquiry | |
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Rgs2flox mice possess loxP sites flanking exons 2-4 of the regulator of G-protein signaling 2 (Rgs2) gene. These mice may be useful for studying hypertension and atherosclerosis, as well as neurodegenerative diseases, such as Alzheimer's Disease, and some cancers.
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| B6.Cg-Snord116tm1Uta/J (Cat. No.: CEMM-07250095) | Inquiry | |
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As deletions of the Snord116 cluster are associated with Prader-Willi syndrome (PWS), mice carrying the 2-loxP (floxed) allele may be useful in generating conditional mutations for studying the role of Snord116 in growth and feeding regulation, mechanisms of obesity, and pathophysiology of Prader-Willi syndrome.
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| STOCK Igs2tm1(ACTB-EGFP, -tdTomato)Zng/J (Cat. No.: CEMM-07250486) | Inquiry | |
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GT11ML (MADM-ML-11GT) mice are designed for MADM (mosaic analysis with double markers), and must be crossed to mice harboring a reciprocal mutation at the same locus (TG11ML;). Compared to the single loxP approach of the original MADM designs, the multiple self-recognizing lox variant sites present in the MADM-ML system result in significantly improved recombination efficiency (4-8 fold higher) with no negative impact on G2-X segregation percentage (G2-X segregation produces the desired fluorescent homozygous mutant daughter cells). This MADM-ML system allows Cre recombinase-induced fluorescent labeling of daughter cells to ascertain lineal relationships and pleiotropic gene function in multicellular organisms. These mice may also be useful in studies of cell differentiation, mitosis, and imprinting.
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| STOCK Igs2tm2(ACTB-tdTomato, -EGFP)Zng/J (Cat. No.: CEMM-07250487) | Inquiry | |
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These TG11ML (MADM-ML-11TG) mice are designed for MADM (mosaic analysis with double markers), and must be crossed to mice harboring a reciprocal mutation at the same locus (GT11ML). Compared to the single loxP approach of the original MADM designs, the multiple self-recognizing lox variant sites present in the MADM-ML system result in significantly improved recombination efficiency (4-8 fold higher) with no negative impact on G2-X segregation percentage (G2-X segregation produces the desired fluorescent homozygous mutant daughter cells). This MADM-ML system allows Cre and/or FLP recombinase-induced fluorescent labeling of daughter cells to ascertain lineal relationships and pleiotropic gene function in multicellular organisms. These mice may also be useful in studies of cell differentiation, mitosis, and imprinting.
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| B6;129-Shhtm2Amc/J (Cat. No.: CEMM-07250013) | Inquiry | |
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These floxed mutant mice possess loxP sites flanking exon 2 of the Shh gene. This strain may be useful for generating conditional mutations in applications related to in studies of developmental defects resulting from disruption of Shh-dependent pathways.
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For Research Use Only.