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B6.Cg-Rgs2em1Jgro/J
Cat. No.: CEMM-07251121
Common Name: Rgs2flox
Rgs2flox mice possess loxP sites flanking exons 2-4 of the regulator of G-protein signaling 2 (Rgs2) gene. These mice may be useful for studying hypertension and atherosclerosis, as well as neurodegenerative diseases, such as Alzheimer's Disease, and some cancers.
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| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Rgs2em1Jgro
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| Allele Name |
endonuclease-mediated mutation 1
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| Allele Attributes |
Conditional ready (e.g. floxed)
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| Gene Symbol |
Rgs2
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| Gene Name |
regulator of G-protein signaling 2
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| Chromosome |
1
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| MGI Accession ID | show more close |
| Strain of Origin |
(C57BL/6J x SJL/J)F1/J
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| Molecular Note |
CRISPR/Cas9 genome editing uses guide RNAs (ATGAGCTTTACAAGCAGGAT and GCTGGGATGAGAGGCGCACA) toinsert loxP sited in the introns flanking exons 2-4. Rgs2 transcript Rgs2-202 was used as reference for the exon number and the guide sequences.
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| HUSBANDRY | |
|---|---|
| Suggested Controls |
C57BL/6J
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| Breeding Considerations |
When maintaining a live colony, homozygous mice may be bred together.
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| Breeding Strategy |
Heterozygote x Heterozygote
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For Research Use Only.
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