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Mouse Models
Site-specific recombinase (SSR) system is widely used in genetically modification, especially the generation for conditional KO and inducible KO mouse models. For making it more efficient and easier, mouse models with special functions have been generated, such as tissue-specifically expressing Cre, inducible expressing Cre, Split-Cre, floxed (target gene were flanked by loxP sites) mouse, et al.
For assisting our global customers making better breakthrough in their research areas, Creative Biogene offers various of mouse models based on site-specific recombinase systems.
- Floxed Mouse: Floxed mouse models provide a way to study gene function in a controlled and tissue-specific manner, allowing researchers to investigate the roles of specific genes in development, physiology, and disease.
- Reporter Mouse: Reporter mouse models generated with SSR technology offer a means to visualize and study gene expression patterns in a tissue-specific or cell-specific manner. They are invaluable tools in deciphering the intricacies of developmental processes and disease mechanisms.
- Inducible Mouse: Inducible mouse models generated with SSR technology are genetically engineered mouse strains that allow for controlled and temporal regulation of gene expression in specific tissues or cell types.
- Recombinase-expressing Mouse: Recombinase-expressing mouse models are genetically modified mouse models that express Cre recombinase tissue-specifically or temporal-specifically.
If you couldn't find the mouse models you need or you are seeking for other model animals, please check out our gene engineering service or just feel free to contact us and get started with our trustable one-stop service.
Our Mouse Models
| STOCK Nogtm1.1Rmh/J (Cat. No.: CEMM-07250303) | Inquiry | |
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These floxed mutant mice possess loxP sites flanking the coding region of the noggin gene. This strain may have applications in studying bone morphogenetic protein signaling during embryonic development and in postnatal tissues.
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| B6.Cg-Msh2tm2.1Rak/J (Cat. No.: CEMM-07250308) | Inquiry | |
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Msh2LoxP has loxP sites flanking exon 12 of the mutS homolog 2 (E. coli) gene [Msh2]. When bred to mice that express Cre recombinase, the resulting offspring will have the sequences encoding a portion of the essential ATPase domain of MSH2 protein deleted in the cre-expressing tissues. These Msh2LoxP mice may be useful in generating tissue-specific MSH2 deletions for studying DNA mismatch repair (single-nucleotide and insertion/deletion mismatches), as well as tumor development.
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| STOCK Tdgf1tm2.2Mms/J (Cat. No.: CEMM-07250309) | Inquiry | |
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These Cripto2loxP mice possess a loxP-sites flanking exons 3-5 of the teratocarcinoma-derived growth factor 1 (Tdgf1) gene. This strain may be useful for studying embryonic development and tumor growth.
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| B6.Cg-Ccl2tm1.1Pame/J (Cat. No.: CEMM-07250319) | Inquiry | |
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These floxed mutant mice contain loxP sites flanking exons 2-3 of the Ccl2 gene which has been modified with a red fluorescent protein gene (mcherry). Fluorescence is seen in all Ccl2-expressing cells. When these mutant mice are bred to mice that express Cre recombinase, resulting offspring will have exons 2-3, as well as RFP, deleted in the cre-expressing tissue.
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| B6;129P2-Gmnntm1Tjm/J (Cat. No.: CEMM-07250320) | Inquiry | |
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These mice possess loxP sites flanking exons 5-7 of the geminin (Gmnn) gene and have applications in studies related to hematopoietic stem cell growth and differentiation.
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| B6.129P2-Lamc1tm1Strl/J (Cat. No.: CEMM-07250321) | Inquiry | |
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These mutant mice possess a frt-flanked neomycin resistance cassette upstream of exon 2, and loxP sites flanking exon 2 of the Lamc1 gene. This strain may be useful for studying neuronal regeneration, embryonic development, organogenesis, and basement membrane assembly.
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| FVB;129P2-Mettm1Sst/J (Cat. No.: CEMM-07250331) | Inquiry | |
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These c-metfl/fl floxed mutant mice possess loxP sites flanking exon 16 of the met proto-oncogene (Met) sequence. This strain may be useful for studying neuronal growth and development in neuropsychiatric diseases such as schizophrenia and autism.
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| B6.129S1(Cg)-Eomestm1.1Bflu/J (Cat. No.: CEMM-07250333) | Inquiry | |
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These floxed mutant mice possess loxP sites flanking exon 2 of the eomesodermin homolog (Eomes) gene. This strain may be useful for studying T cell-mediated immune response, immune surveillance and editing, and embryonic development.
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| STOCK Sirt6tm1.1Cxd/J (Cat. No.: CEMM-07250335) | Inquiry | |
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These Sirt6Co floxed mutant mice possess loxP sites flanking exons 2-3 of the sirtuin 6 (Sirt6) targeted gene. This strain may be useful for studying glycoloysis, lipid metabolism, and glucose homeostasis.
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| B6.129S6(129S4)-Tfpitm1.1Rdsi/J (Cat. No.: CEMM-07250356) | Inquiry | |
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These mice contain a TFPIFlox allele with loxP sites flanking exon 4 of the Tfpi gene. When bred to mice that express Cre recombinase, the resulting offspring will have the sequences encoding the Kunitz 1 domain of the TFPI protein deleted in cre-expressing tissues. As the TFPI-K1 domain is necessary for TFPI-inhibition of the tissue factor coagulation pathway, these mice may be useful in generating tissue-specific TFPI deletions for such studies, as well as innate immunity, angiogenesis, and lipid metabolism.
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For Research Use Only.