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B6.129S6(129S4)-Tfpitm1.1Rdsi/J
Cat. No.: CEMM-07250356
These mice contain a TFPIFlox allele with loxP sites flanking exon 4 of the Tfpi gene. When bred to mice that express Cre recombinase, the resulting offspring will have the sequences encoding the Kunitz 1 domain of the TFPI protein deleted in cre-expressing tissues. As the TFPI-K1 domain is necessary for TFPI-inhibition of the tissue factor coagulation pathway, these mice may be useful in generating tissue-specific TFPI deletions for such studies, as well as innate immunity, angiogenesis, and lipid metabolism.
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| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Tfpitm1.1Rdsi
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| Allele Name |
targeted mutation 1.1
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| Allele Attributes |
Conditional ready (e.g. floxed); No functional change
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| Gene Symbol |
Tfpi
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| Gene Name |
tissue factor pathway inhibitor
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| Chromosome |
2
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| MGI Accession ID | show more close |
| Strain of Origin |
129S6/SvEvTac
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| Molecular Note |
A FRT flanked Neomycin cassette was inserted within intron 3 and exon 4 was floxed by homologous recombination. The selection cassette was removed by flp mediated recombination.
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| HUSBANDRY | |
|---|---|
| Suggested Controls |
C57BL/6J Wild-type from the colony
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| Breeding Considerations |
When maintaining a live colony, homozygous mice may be bred together.
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For Research Use Only.
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