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Mouse Models
Site-specific recombinase (SSR) system is widely used in genetically modification, especially the generation for conditional KO and inducible KO mouse models. For making it more efficient and easier, mouse models with special functions have been generated, such as tissue-specifically expressing Cre, inducible expressing Cre, Split-Cre, floxed (target gene were flanked by loxP sites) mouse, et al.
For assisting our global customers making better breakthrough in their research areas, Creative Biogene offers various of mouse models based on site-specific recombinase systems.
- Floxed Mouse: Floxed mouse models provide a way to study gene function in a controlled and tissue-specific manner, allowing researchers to investigate the roles of specific genes in development, physiology, and disease.
- Reporter Mouse: Reporter mouse models generated with SSR technology offer a means to visualize and study gene expression patterns in a tissue-specific or cell-specific manner. They are invaluable tools in deciphering the intricacies of developmental processes and disease mechanisms.
- Inducible Mouse: Inducible mouse models generated with SSR technology are genetically engineered mouse strains that allow for controlled and temporal regulation of gene expression in specific tissues or cell types.
- Recombinase-expressing Mouse: Recombinase-expressing mouse models are genetically modified mouse models that express Cre recombinase tissue-specifically or temporal-specifically.
If you couldn't find the mouse models you need or you are seeking for other model animals, please check out our gene engineering service or just feel free to contact us and get started with our trustable one-stop service.
Our Mouse Models
| STOCK Slc32a1tm1Lowl/J (Cat. No.: CEMM-07250247) | Inquiry | |
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These floxed Slc32a1tm1Lowl (also commonly referred to as Vgatflox/flox) mice possess loxP sites flanking exon 2 of the Slc32a1 (or Vgat) gene. These mice may be useful for studying the physiological effect of GABAergic neurotransmission on the regulation of energy balance.
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| STOCK Slc17a6tm1Lowl/J (Cat. No.: CEMM-07250248) | Inquiry | |
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Vglut2flox mutant mice possess loxP sites flanking exon 2 of the solute carrier family 17 (sodium-dependant inorganic phosphate cotransporter), member 6 (Slc17a6 or Vglut2) gene. These mice may be useful for studying the effect of transport, packaging, and release of glutamate from ventromedial hypothalamic (VMH) neurons on hypoglycemia.
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| STOCK Agrptm1(cre)Lowl/J (Cat. No.: CEMM-07250249) | Inquiry | |
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AgRP-IRES-Cre knock-in mice have IRES-Cre inserted downstream of the stop codon of the agouti related neuropeptide locus. Cre recombinase expression is observed in agouti-related protein secreting neurons. These mice may be useful for studying the physiological functions of GABA neurotransmission in agouti-related protein neurons in the hypothalamus. Sequencing analysi revealed that the gene targeting used to create the Agrp-Ires-Cre allele also resulted in a duplication of chromosome 8 genomic sequence at least 53 kb in size (including 3 loci) that inserted into intron 1 of the nearby Ripor1 locus.
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| STOCK Epha4tm1.1Bzh/J (Cat. No.: CEMM-07250251) | Inquiry | |
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These floxed mutant mice possess loxP sites flanking exon 3 of the Epha4 gene. This strain may be useful for generating conditional mutations in applications related to neuron development and inter-cellular communication.
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| B6.129P2-Gt(ROSA)26Sortm1Nik/J (Cat. No.: CEMM-07250269) | Inquiry | |
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These 3373 S-state Cre-sensitive (3373 3SCS) mice contain a construct designed to insert (from 5' to 3') a splice acceptor (SA) sequence, a loxP site, a puromycin selection cassette, an SV40 polyadenylation (polyA) cassette, another loxP site, tdTomato open reading frame (ORF), an internal ribosome entry site (IRES) fused to an enhanced green fluorescent protein (GFP) flanked by 3373 loxP sites, followed by a second polyA cassette. The loxP sites flanking the 5' polyA cassette are in opposite orientation to the loxP sites flanking the 3' IRES-GFP cassette, and all are modified allowing for only 10% of the recombination efficiency of native loxP sites. This vector was inserted into the Gt(ROSA)26Sor locus allowing for widespread expression. These 3373 3SCS mice are of general use for detecting cells that have expressed the Cre recombinase, for Cre recombinase-based lineage marking experiments, and in particular for applications in which it is useful to discriminate cells that differ in how much Cre recombinase they have expressed. Cre recombinase-dependent excision of IRES-GFP in the 3373 3SCS strain occurs at approximately one third the efficiency it does in the 5172 3SCS strain
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| STOCK Igs2tm1(ACTB-EGFP, -tdTomato)Luo/J (Cat. No.: CEMM-07250282) | Inquiry | |
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These intergenic site 2 (commonly referred to as MADM-11GT) targeted mutants are useful for generating fluorescent double markers in mice for studies to ascertain lineal relationships and pleiotropic gene function in multicellular organisms, and in studies of cell differentiation and mitosis.
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| STOCK Igs2tm2(ACTB-tdTomato, -EGFP)Luo/J (Cat. No.: CEMM-07250283) | Inquiry | |
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The MADM-11TG allele with enhanced green fluorescent protein is inserted into the Igs2 (formerly Hipp11) locus on chromosome 11. This MADM system allows Cre- or FLP-mediated fluorescent labeling of daughter cells to ascertain lineal relationships and pleiotropic gene function in multicellular organisms. These mice may also be useful in studies of cell differentiation and mitosis.
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| B6.129S2(FVB)-Pak4tm2.1Amin/J (Cat. No.: CEMM-07250295) | Inquiry | |
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This Pak4-floxed strain may be useful for studying the role of Pak4 in the development of extraembryonic tissue, embryonic vasculature, and the placenta.
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| B6.129S6-Itga8tm1.1Rdav/J (Cat. No.: CEMM-07250301) | Inquiry | |
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These f(α8) conditional mutant mice have loxP sites flanking the exons encoding the transmembrane and the cytoplasmic domains of the Itga8 gene (also called integrin alpha 8, alpha8-integrin, or α8-integrin). These f(α8) mutant mice may be useful in generating conditional mutations for studying the role of Itga8 transmembrane cell adhesion receptors in neuronal function in the developing and adult central nervous system, including intracellular signaling, behavior, synaptic plasticity, and memory formation.
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| C.129P2(Cg)-Il4/Il13tm1.1Lky/J (Cat. No.: CEMM-07250302) | Inquiry | |
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These Il4/Il13flox mutant mice harbor loxP-flanked sequences that span the adjacent genes Il4 and Il13, enabling the conditional disruption of both genes simultaneously via cre-induced recombination.
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For Research Use Only.