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Mouse Models
Site-specific recombinase (SSR) system is widely used in genetically modification, especially the generation for conditional KO and inducible KO mouse models. For making it more efficient and easier, mouse models with special functions have been generated, such as tissue-specifically expressing Cre, inducible expressing Cre, Split-Cre, floxed (target gene were flanked by loxP sites) mouse, et al.
For assisting our global customers making better breakthrough in their research areas, Creative Biogene offers various of mouse models based on site-specific recombinase systems.
- Floxed Mouse: Floxed mouse models provide a way to study gene function in a controlled and tissue-specific manner, allowing researchers to investigate the roles of specific genes in development, physiology, and disease.
- Reporter Mouse: Reporter mouse models generated with SSR technology offer a means to visualize and study gene expression patterns in a tissue-specific or cell-specific manner. They are invaluable tools in deciphering the intricacies of developmental processes and disease mechanisms.
- Inducible Mouse: Inducible mouse models generated with SSR technology are genetically engineered mouse strains that allow for controlled and temporal regulation of gene expression in specific tissues or cell types.
- Recombinase-expressing Mouse: Recombinase-expressing mouse models are genetically modified mouse models that express Cre recombinase tissue-specifically or temporal-specifically.
If you couldn't find the mouse models you need or you are seeking for other model animals, please check out our gene engineering service or just feel free to contact us and get started with our trustable one-stop service.
Our Mouse Models
| STOCK Shank3tm5.1Gfng/J (Cat. No.: CEMM-07250700) | Inquiry | |
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Shank3fx is a cre-dependent FLEx switch allele containing an inverted Shank3 PDZ domain (exons 13-16) flanked by inward-facing tandem lox sites (lox2272:loxP). In the absence of Cre recombinase, this functions as a knockout allele and homozygotes exhibit autistic-like characteristics. Subsequent exposure to Cre recombinase that places the Shank3 PDZ domain into the proper orientation for expression results in restored expression of most major SHANK3 isoforms in those cells. These mice allow cre-inducible restoration of SHANK3 expression, and may be useful for studying autism spectrum disorder (ASD), Phelan-McDermid syndrome and schizophrenia.
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| STOCK Gad2tm2(cre)Zjh/J (Cat. No.: CEMM-07250204) | Inquiry | |
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Gad2-IRES-Cre knock-in mice have Cre recombinase expression directed to GAD2 positive neurons. These mice may be used to generate conditional mutations for studying GAD2 cell populations.
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| B6J.Cg-Ssttm2.1(cre)Zjh/MwarJ (Cat. No.: CEMM-07250703) | Inquiry | |
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Sst-IRES-Cre knock-in mice express Cre recombinase in somatostatin-expressing neurons. These mice may be useful in studying dendritic inhibitory interneurons such as Martinotti cells and Oriens-Lacunosum-Moleculare cells. While Sst-IRES-Cre was designed as a 3' knock-in allele, additional characterization indicates it has significantly diminished endogenous Sst expression - see details below. As such, researchers should consider using heterozygous Sst-IRES-Cre mice and wildtype littermate controls in all their studies.
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| B6;129S-Gt(ROSA)26Sortm35.1(CAG-aop3/GFP)Hze/J (Cat. No.: CEMM-07250244) | Inquiry | |
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The Ai35D (or Ai35Δneo) allele has a floxed-STOP cassette preventing transcription of the downstream Arch-GFP fusion gene. Exposure to Cre recombinase that deletes the STOP cassette results in Arch-GFP expression. These Ai35D mice are useful for optogenetic studies to express an inhibitory opsin that effectively silences the activity of cortical neurons (and perhaps other excitable cell types such as muscle cells and immune cells).
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| B6.129S4-Gt(ROSA)26Sortm1Sor/J (Cat. No.: CEMM-07250007) | Inquiry | |
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These Gt(ROSA)26Sortm1Sor targeted mutant mice carry a loxP flanked neo cassette upstream of a β-galactosidase (lacZ) sequence. Removal of the neo cassette by cre recombination results in lacZ expression in cre-expressing tissues of the offspring. These mutant mice may be used as a Cre-reporter strain to test the tissue/cellular expression pattern of cre expressing mice.
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| B6;129-Igs2tm5(CAG-tTA2, -TagBFP)Luo/J (Cat. No.: CEMM-07250888) | Inquiry | |
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TB (tTA2-BFP) mice have a floxed-STOP cassette preventing transcription of the downstream genes - tTA2 (tetracycline-controlled transactivator) and mTagBFP (nuclear-targeted monomeric blue fluorescent protein). TB mice are useful for Cre-dependent Tet-Off applications, as well as a Cre-dependent fluorescent reporter tool strain.
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| B6;129S2-Syngap1tm2Geno/RumbJ (Cat. No.: CEMM-07250725) | Inquiry | |
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The SYNGAP1lx-st conditional rescue knock-in allele has a loxP-flanked neo-STOP cassette upstream of exon 6 of the synaptic RasGAP (SynGAP) gene; resulting in disrupted expression of full-length SynGAP and expression of a truncated/inactive SynGAP protein. These mice allow Cre recombinase-inducible restoration of full-length SynGAP expression. SYNGAP1lx-st mice may be useful Cre-lox studies of synapse development (specifically in dendritic spine), cognitive and behavioral maturation, intellectual disability and autism spectrum disorder.
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| C57BL/6-Esr1tm2.1(cre)And/J (Cat. No.: CEMM-07250376) | Inquiry | |
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The Esr1cre knock-in allele has Cre recombinase expression directed to estrogen receptor 1 alpha (Esr1 or ERα)-expressing cells by the endogenous Esr1 promoter/enhancer elements; specifically in the ventrolateral subdivision of the ventromedial hypothalamus that, like wildtype mice, is greater in females than males. Expression is also observed in arcuate nucleus (ARH). These Esr1-Cre knock-in mice may be useful for studying the function of this ligand-inducible transcription factor in social interactions, neuronal differentiation, sympathetic nervous system development, hypothalamus, female reproductive organs (endometrium and ovarian stroma cells), and male efferent duct epithelial cells. They may also be useful for studying ERα-positive breast cancer and steroid hormone-induced malignancies. Esr1-Cre knock-in mice are available on a C57BL/6N background and a C57BL/6J background.
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| B6N.129S6(Cg)-Esr1tm1.1(cre)And/J (Cat. No.: CEMM-07250374) | Inquiry | |
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The Esr1cre knock-in allele has Cre recombinase expression directed to estrogen receptor 1 alpha (Esr1 or ERα)-expressing cells by the endogenous Esr1 promoter/enhancer elements; specifically in the ventrolateral subdivision of the ventromedial hypothalamus that, like wildtype mice, is greater in females than males. Expression is also observed in arcuate nucleus (ARH). These Esr1-Cre knock-in mice may be useful for studying the function of this ligand-inducible transcription factor in social interactions, neuronal differentiation, sympathetic nervous system development, hypothalamus, female reproductive organs (endometrium and ovarian stroma cells), and male efferent duct epithelial cells. They may also be useful for studying ERα-positive breast cancer and steroid hormone-induced malignancies. Esr1-Cre knock-in mice are available on a C57BL/6N background and a C57BL/6J background.
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| STOCK Tg(CAG-Bgeo, -DsRed*MST)1Nagy/J (Cat. No.: CEMM-07250025) | Inquiry | |
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These Z/RED transgenic mice express beta-galactosidase (lacZ) under the control of the chicken beta actin promoter coupled with the cytomegalovirus (CMV) immediate early enhancer. When crossed with a Cre recombinase-expressing strain, lacZ expression is replaced with red fluorescent protein (DsRed*MST) expression in tissues expressing Cre recombinase. This double reporter system makes it possible to distinguish a lack of reporter expression from a lack of Cre recombinase expression while providing a means to assess Cre excision activity in live animals and cells.
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For Research Use Only.