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Mouse Models
Site-specific recombinase (SSR) system is widely used in genetically modification, especially the generation for conditional KO and inducible KO mouse models. For making it more efficient and easier, mouse models with special functions have been generated, such as tissue-specifically expressing Cre, inducible expressing Cre, Split-Cre, floxed (target gene were flanked by loxP sites) mouse, et al.
For assisting our global customers making better breakthrough in their research areas, Creative Biogene offers various of mouse models based on site-specific recombinase systems.
- Floxed Mouse: Floxed mouse models provide a way to study gene function in a controlled and tissue-specific manner, allowing researchers to investigate the roles of specific genes in development, physiology, and disease.
- Reporter Mouse: Reporter mouse models generated with SSR technology offer a means to visualize and study gene expression patterns in a tissue-specific or cell-specific manner. They are invaluable tools in deciphering the intricacies of developmental processes and disease mechanisms.
- Inducible Mouse: Inducible mouse models generated with SSR technology are genetically engineered mouse strains that allow for controlled and temporal regulation of gene expression in specific tissues or cell types.
- Recombinase-expressing Mouse: Recombinase-expressing mouse models are genetically modified mouse models that express Cre recombinase tissue-specifically or temporal-specifically.
If you couldn't find the mouse models you need or you are seeking for other model animals, please check out our gene engineering service or just feel free to contact us and get started with our trustable one-stop service.
Our Mouse Models
| STOCK Ntrk2tm1Ddg/J (Cat. No.: CEMM-07250471) | Inquiry | |
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These mice carry a floxed F616A mutation in mouse Ntrk2 (neurotrophic tyrosine kinase, receptor, type 2; also called TrkB). Signaling is effectively blocked by application of 1NMPP1. This strain is useful in studies of nerve growth and survival.
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| C57BL/6N-Il1r1tm1Quan/J (Cat. No.: CEMM-07250524) | Inquiry | |
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The interleukin 1 type I receptor restore allele (IL-1R1r) is a functional null prior to Cre recombinase exposure. These mice allow Cre recombinase-inducible restoration of functional IL-1R1 expression, and visualization of IL-1R1-expressing cells with concordant labeling of IL-1R1 mRNA (by tdTomato fluorescence) and protein (by 3xHA epitope). IL-1R1r mice may be useful for studying cell-type-specific functions of IL-1R1 in neuroimmunity and neuroinflammation.
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| B6.Cg-Gt(ROSA)26Sortm80.1(CAG-COP4*L132C/EYFP)Hze/J (Cat. No.: CEMM-07250556) | Inquiry | |
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The Ai80(RCFL-CatCh)-D (or Ai80D) conditional allele has both an frt-flanked STOP cassette and a loxP-flanked STOP cassette preventing transcription of the calcium translocating channelrhodopsin (CatCh; an L132C mutant channelrhodopsin with enhanced Ca2+ permeability, accelerated response kinetics and ~70-fold greater light sensitivity) and EYFP. After removal of the flanked STOP cassettes by FLP- and Cre-recombination, CatCh/EYFP expression is expected in cells/tissues expressing both FLP recombinase and Cre recombinase. Subsequent illumination of CatCh-expressing cells with blue-to-green light leads to reversible photostimulation of action potential firing/neural activity in these cells.
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| B6.129-Gt(ROSA)26Sortm1(CAG-CHRM4*, -mCitrine)Ute/J (Cat. No.: CEMM-07250590) | Inquiry | |
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R26-LSL-Gi-DREADD mice were designed to have Cre recombinase-inducible expression of a CAG promoter-driven HA-hM4Di-pta-mCitrine from the Gt(ROSA)26Sor locus. Following Cre-mediated removal of an upstream floxed-STOP cassette, higher expression levels of HA-tagged hM4Di and mCitrine yellow fluorescent protein is observed.
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| B6.Cg-Gt(ROSA)26Sortm3.3(CAG-EGFP, -CHRM3*/mCherry/Htr2a)Pjen/J (Cat. No.: CEMM-07250623) | Inquiry | |
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RC::L-hM3Dq is a Gq-coupled DREADD allele with a cre-dependent FLEx switch containing an eGFP sequence and an inverted hM3Dq/mCherry/2ACT88 fusion protein. Upon exposure to Cre recombinase, the widespread and robust eGFP fluorescence may be replaced with somatodendritic hM3Dq/mCherry expression. The hM3Dq DREADD induces the canonical Gq pathway (depolarization/activation) specifically following administration of its pharmacologically inert ligand (CNO). The RC::L-hM3Dq allele and its derivatives permit chemogenetic/pharmacogenetic activation defined by Cre recombinase expression.
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| B6J.B6NTac(SJL)-Kcnu1tm1.1Clin/J (Cat. No.: CEMM-07250665) | Inquiry | |
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Slo3-EGFP+ floxed mice possess loxP sites flanking exon 27 of the Kcnu1 gene and a green fluorescent protein sequence. This strain may be useful for studying spermatozoan pH-dependent potassium ion currents and their effect on fertility and fertilization.
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| B6.Cg-Tg(Dmp1-cre/ERT2)D77Pdp/J (Cat. No.: CEMM-07250740) | Inquiry | |
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has been discontinued. We recommend B6.Cg-Tg(Dmp1-cre/ERT2)0022Pdp/IkalJ as a replacement.10kb-Dmp1-Cre-ERT2 transgenic line D77 has the 10 kbp promoter/enhancer sequences from the mouse dentin matrix protein 1 locus (DMP1) directing tamoxifen-inducible Cre recombinase (cre/ERT2) expression to osteocytes, some mature osteoblasts and bone lining cells.
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| B6;129-Gt(ROSA)26Sortm1(Ptbp1)Szhg/J (Cat. No.: CEMM-07250763) | Inquiry | |
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Rosa26LSL-FL-Ptbp1 mice contain a floxed STOP cassette followed by a FLAG-tagged polypyrimidine tract binding protein 1 (Ptbp1) cDNA and an IRES/mCherry cassette. This strain may be useful when studying neuronal pre-mRNA splicing.
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| B6.129(Cg)-Rettm13.1Jmi/SjnJ (Cat. No.: CEMM-07250764) | Inquiry | |
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These Ret-EGFP knock-in/knock-out mice express the EGFP reporter under the control of the endogenous promoter and are useful in studies of neural and renal development.
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| B6.Cg-Tg(CAG-GFP, -EIF4EBP1)2877Als/J (Cat. No.: CEMM-07250772) | Inquiry | |
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The Tg-4EBP1wt transgene has a floxed-GFP-3xSTOP cassette preventing expression of human wildtype EIF4EBP1. These mice are a Cre recombinase-inducible overexpression model, and may be useful for studies involving mTOR complex 1 signaling and metabolism. Tg-4EBP1wt mice also serve as a control for the similarly-designed Tg-4EBP1mt mice which have Cre recombinase-inducible expression of constitutively active EIF4EBP1.
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For Research Use Only.