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B6.129(Cg)-Rettm13.1Jmi/SjnJ
Cat. No.: CEMM-07250764
Common Name: RET-GFP KO; Ret-EGFP
These Ret-EGFP knock-in/knock-out mice express the EGFP reporter under the control of the endogenous promoter and are useful in studies of neural and renal development.
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| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Rettm13.1Jmi
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| Allele Name |
targeted mutation 13.1
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| Allele Attributes |
Reporter; Null/Knockout
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| Gene Symbol |
Ret
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| Gene Name |
ret proto-oncogene
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| Chromosome |
6
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| Expressed Genes |
GFP, Green Fluorescent Protein
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| MGI Accession ID | show more close |
| Site of Expression |
EGFP is expressed in kidneys, enteric nervous system, testis, dorsal root ganglion, spinal motor neurons, and midbrain dopaminergic neurons of the substantia nigra compacta and the ventral tegmental area.
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| Strain of Origin |
(129X1/SvJ x 129S1/Sv)F1-Kitl+
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| Molecular Note |
A loxP site and the human RET (RET9) sequence was inserted with a floxEGFPFRT neo-FRT cassette. The neo was removed by flp mediated recombination. This allele allows EGFP expression upon the Cre mediated deletion of floxed cDNA from exon 1. Cre-mediated recombination removed the cDNA and allows for the expression of the reporter gene.
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For Research Use Only.
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