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C57BL/6N-Tg(Slc32a1-icre/ERT2)3Gloss/J
Cat. No.: CEMM-07250311
Common Name: VGAT-iCreER
These VGAT-iCreER transgenic mice express a tamoxifen-inducible Cre recombinase under the control of the mouse Slc32a1 promoter region and may be useful for generating conditional mutations for studying gain or loss of function and/or fate mapping throughout the brain in neurons that structurally resemble interneurons.
Inquiry
| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Tg(Slc32a1-icre/ERT2)3Gloss
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| Allele Name |
transgene insertion 3
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| Allele Attributes |
Recombinase-expressing; Inducible
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| Gene Symbol |
Tg(Slc32a1-icre/ERT2)3Gloss
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| Gene Name |
transgene insertion 3
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| Chromosome |
UN
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| Expressed Genes |
ESR1, estrogen receptor 1, human; Cre, Cre recombinase, bacteriophage P1
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| MGI Accession ID | show more close |
| Site of Expression |
Tamoxifen administration induces Cre recombination throughout the brain in neurons that structurally resemble interneurons.
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| Strain of Origin |
C57BL/6NTac
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| Molecular Note |
The mouse bacterial artificial chromosome (BAC) RP23-392P11 containing the Slc32a1, solute carrier family 32 (GABA vesicular transporter), member 1, gene, was modified by insertion of sequence encoding iCreER at the Slc32a1 translation initiation ATG, and addition of a Kozak sequence upstream of the ATG. This BAC also contains these additional genes Adig (adipogenin), Arhgap40 (Rho GTPase activating protein 40), AK134637, BC072662, and Actr5 (P5 actin-related protein 5 homolog (yeast)). The modified BAC was used to generate the VGAT-iCreER transgene, which was microinjected into C57BL/6NTac fertilized eggs. Founder line 3 was subsequently established.
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| HUSBANDRY | |
|---|---|
| Suggested Controls |
Noncarrier
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| Breeding Considerations |
When maintaining a live colony, these mice can be bred as homozygotes.
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For Research Use Only.
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