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B6.129S4-Mtortm1.2Koz/J
Cat. No.: CEMM-07250210
Common Name: mTORfl
These mTORfl mutant mice harbor loxP sites flanking exons 1-5 of the mechanistic target of rapamycin (serine/threonine kinase) locus, and may be useful in generating conditional mutations for studying mTOR and mTOR complex signaling; including regulation of cell growth, cell proliferation/differentiation, cell survival, cancer, tumor cell motility and metastasis, the RTK-PI3K-mTOR signaling axis, stem cell development, cytokine signaling, and T cell lineage commitment.
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| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Mtortm1.2Koz
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| Allele Name |
targeted mutation 1.2
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| Allele Attributes |
Conditional ready (e.g. floxed); No functional change
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| Gene Symbol |
Mtor
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| Gene Name |
mechanistic target of rapamycin kinase
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| Chromosome |
4
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| MGI Accession ID | show more close |
| Strain of Origin |
129S4/SvJae
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| Molecular Note |
A loxP site was inserted upstream of exon 1 and a floxed neo cassette was inserted downstream of exon 5. Transient Cre expression in ES cells removed the neo cassette Creating this allele.
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| HUSBANDRY | |
|---|---|
| Suggested Controls |
C57BL/6J
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| Breeding Considerations |
When maintaining a live colony, homozygous mice may be bred together.
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| Breeding Strategy |
Homozygote x Homozygote
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For Research Use Only.
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