B6.FVB(129S6)-Tg(Drd1a-cre)AGsc/KndlJ

Cat. No.: CEMM-07250795

Common Name: D1-Cre (C57BL/6J); B6J.D1-Cre; B6J.D1Cre

D1-Cre YAC transgenic mice have Cre recombinase expressed from the mouse Drd1a promoter. The spatio-temporal pattern of Cre expression in dopaminoceptive neurons is reported to closely recapitulate that of the endogenous Drd1a gene in embryonic and adult stages.

Inquiry

Status	Live Mouse Frozen Embryo
Age	4 weeks 12 weeks Customized Age
Sex	Male Female

GENETICS
Allele Symbol	Tg(Drd1a-cre)AGsc show more close
Allele Name	transgene insertion A show more close
Allele Attributes	Recombinase-expressing show more close
Gene Symbol	Tg(Drd1a-cre)AGsc show more close
Gene Name	transgene insertion A show more close
Chromosome	UN show more close
Expressed Genes	Cre, Cre recombinase, bacteriophage P1 show more close
MGI Accession ID	3761818 show more close
Site of Expression	Cre is expressed in dopaminoceptive neurons. show more close
Strain of Origin	FVB/N show more close
Molecular Note	A YAC containing the Cre open reading frame with a nuclear localization signal and under the control of a Drd1a promoter was used to Create a transgene. Expression was confirmed through crosses with three reporter lines and localized to the major dopaminoceptive regions. Line A contains 3 copies of the transgene. show more close

HUSBANDRY
Suggested Controls	C57BL/6J show more close
Breeding Considerations	D1-Cre YAC transgenic mice were bred to C57BL/6J inbred mice for several generations using a marker-assisted, speed congenic approach to establish this congenic strain. When maintaining the live congenic colony, hemizygous mice may be bred with wildtype (non-carrier) mice from the colony. To date, it has not been attempted to make this strain homozygous. show more close
Breeding Strategy	Hemizygote x Noncarrier; Noncarrier x Hemizygote show more close

For Research Use Only.