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B6.129S1(SJL)-Nkx2-5tm2(cre)Rph/J
Cat. No.: CEMM-07250544
Common Name: Nkx2.5-Cre
The Nkx2-5IRESCre allele expresses an IRES-Cre fusion protein in cardiac crescent and heart tube progenitor cells.
Inquiry
| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Nkx2-5tm2(cre)Rph
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| Allele Name |
targeted mutation 2
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| Allele Attributes |
Recombinase-expressing; No functional change
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| Gene Symbol |
Nkx2-5
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| Gene Name |
NK2 homeobox 5
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| Chromosome |
17
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| Expressed Genes |
Cre, Cre recombinase, bacteriophage P1
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| MGI Accession ID | show more close |
| Site of Expression |
Mice carrying this allele express an IRES-Cre fusion protein in cardiac crescent and heart tube progenitor cells.
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| Strain of Origin |
129S1/Sv-Oca2+ Tyr+ Kitl+
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| Molecular Note |
Sequence encoding Cre recombinase adjoined to an IRES was inserted into the 3' UTR of the endogenous locus via homologous recombination. A single FRT site remained in the UTR after an FRT flanked hygromycin selection cassette was excised. A lack of observed allele complementation indicated that the inserted sequence did not significantly affect expression of the endogenous locus.
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| HUSBANDRY | |
|---|---|
| Suggested Controls |
C57BL/6J
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| Breeding Considerations |
When maintaining a live colony, homozygous mice may be bred together.
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| Breeding Strategy |
Homozygote x Homozygote
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For Research Use Only.
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