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B6.129S4(SJL)-Flcntm1Btt/JdchJ
Cat. No.: CEMM-07250692
Common Name: BHDflox (Flcnflox)
The BHDflox allele (Flcnflox) has loxP sites flanking exons 3-4 of the folliculin gene. Cre recombinase-induced removal of the floxed sequence creates a null allele. These BHDflox mice are useful in studying Birt-Hogg-Dube (BHD) syndrome; a rare cancer disorder caused by Flcn mutations that manifests in lung, kidney and skin, and also exhibits characteristics of ciliopathies.
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| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Flcntm1Btt
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| Allele Name |
targeted mutation 1
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| Allele Attributes |
Conditional ready (e.g. floxed); No functional change
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| Gene Symbol |
Flcn
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| Gene Name |
folliculin
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| Chromosome |
11
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| MGI Accession ID | show more close |
| Strain of Origin |
129S4/SvJaeSor
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| Molecular Note |
Exons 3 and 4 were flanked by loxP sites and an FRT flanked neo cassette was inserted after the second loxP site via homologous recombination. The neo cassette was subsequently removed via Flp mediated recombination.
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| HUSBANDRY | |
|---|---|
| Suggested Controls |
C57BL/6J Wild-type from the colony
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| Breeding Considerations |
When maintaining a live colony, heterozygous mice may be bred together, to wildtype mice from the colony or to C57BL/6J inbred mice. Alternatively, homozygous mice may be bred together.
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| Breeding Strategy |
Heterozygote x Heterozygote
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For Research Use Only.
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