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B6.SJL-Slc6a3tm1.1(cre)Bkmn/J
Cat. No.: CEMM-07250056
DATIREScre knock-in mice have Cre recombinase expression directed to dopaminergic neurons, without disrupting endogenous dopamine transporter expression. These mice may be useful for studying gene function in dopaminergic neurons, such as drug addiction, Parkinson's disease and Attention Deficit-Hyperactivity Disorder (ADHD).
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| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Slc6a3tm1.1(cre)Bkmn
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| Allele Name |
targeted mutation 1.1
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| Allele Attributes |
Recombinase-expressing
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| Gene Symbol |
Slc6a3
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| Gene Name |
solute carrier family 6
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| Chromosome |
13
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| Expressed Genes |
Cre, Cre recombinase, bacteriophage P1
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| MGI Accession ID | show more close |
| Site of Expression |
Cre recombinase activity is observed as early as embryonic day 15, and co-localizes with endogenous gene expression in adult dopaminergic cell groups (substantia nigra (SN) and ventral tegmental area (VTA), as well as in the retrorubral field). Lesser Cre recombinase activity occurs in adult olfactory bulb glomeruli, mimicking the known lower Slc6a3 (or DAT) expression in this tissue.
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| Strain of Origin |
Not Specified
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| Molecular Note |
An FRT flanked neo was removed from the locus, leaving Cre recombinase cDNA in the 3' UTR to allow bicistronic mRNA expression.
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For Research Use Only.
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