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B6.129(SJL)-Sorbs2tm1.1Gfng/J
Cat. No.: CEMM-07250684
Common Name: Sorbs2F
The ArgBP2 exon12 flox allele (Sorbs2F) has loxP sites flanking exon 12 of the Sorbs2 gene. Removal of the floxed sequence creates a null allele. As the floxed exon is conserved in nearly all ArgBP2 isoforms, these mice may be useful in studying non-neuronal ArgBP2 (congenital heart disease/cardiology and cancer metastasis/oncology research) as well as neuronal ArgBP2 (nArgBP2; dendritic development and memory formation).
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| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Sorbs2tm1.1Gfng
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| Allele Name |
targeted mutation 1.1
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| Allele Attributes |
Conditional ready (e.g. floxed); No functional change
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| Gene Symbol |
Sorbs2
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| Gene Name |
sorbin and SH3 domain containing 2
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| Chromosome |
8
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| MGI Accession ID | show more close |
| Strain of Origin |
(129X1/SvJ x 129S1/Sv)F1-Kitl+
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| Molecular Note |
The targeting vector was designed with a loxP::FRT SV40 promoter-Neo-pA-FRT cassette 389 bp upstream of exon 12, and a loxP site 676 bp downstream of exon 12. Flp-mediated recombination removed the FRT flanked neo cassette.
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| HUSBANDRY | |
|---|---|
| Suggested Controls |
C57BL/6J
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| Breeding Considerations |
When maintaining a live colony, heterozygous mice may be bred together, to wildtype mice from the colony or to C57BL/6J inbred mice. Alternatively, homozygous mice may be bred together.
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For Research Use Only.
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