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B6(Cg)-Ndnftm1.1(cre/ERT2)Ispgl/J

Cat. No.: CEMM-07251004

Common Name: Ndnf-IRES-CreERT2
Ndnf-IRES-CreERT2 knock-in mice have a cre/ERT2 fusion gene inserted into the 3' UTR in exon 4 of the neuron-derived neurotrophic factor (Ndnf) gene. These mice retain endogenous Ndnf expression and may be used to generate conditional mutations for studying gain-or-loss of function, fate mapping and/or circuit dissection of NDNF+ cell populations.
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Status Live Mouse
Frozen Embryo
Age 4 weeks
12 weeks
Customized Age
Sex Male
Female
GENETICS
Allele Symbol
Ndnftm1.1(cre/ERT2)Ispgl
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Allele Name
targeted mutation 1.1
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Allele Attributes
Recombinase-expressing; Inducible
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Gene Symbol
Ndnf
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Gene Name
neuron-derived neurotrophic factor
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Chromosome
6
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MGI Accession ID
6393601
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Site of Expression
Expression is evident in neocortical layer 1 (L1) GABAergic interneurons (INs) in the adult mouse brain, and becomes restricted to GABAergic interneurons only during the third postnatal week.
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Strain of Origin
C57BL/6J
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Molecular Note
The targeting vector was designed to insert an internal ribosome entry site (IRES) fused to a Cre/ERT2 fusion gene (Cre recombinase fused to a human estrogen receptor ligand binding domain) into the 3' UTR in exon 4 of the neuron-derived neurotrophic factor (Ndnf) gene. The construct also included a FRT flanked neomycin resistance cassette. After homologouse recombination in ES cells, the resulting chimeric mice were bred with flp recombinase expressing mice to remove the neo cassette.
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HUSBANDRY
Suggested Controls
C57BL/6J
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Breeding Considerations
When maintaining a live colony, homozygous mice may be bred together.
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Breeding Strategy
Heterozygote x Heterozygote
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For Research Use Only.
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