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B6;129S4-Tcf3tm4Zhu/J
Cat. No.: CEMM-07250102
Common Name: E2Aloxp
This Tcfe2a, transcription factor E2a, targeted mutation strain may be useful in generating conditional mutations for studying B and T cell development and for other immunological applications.
Inquiry
| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Tcf3tm4Zhu
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| Allele Name |
targeted mutation 4
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| Allele Attributes |
Conditional ready (e.g. floxed); No functional change
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| Gene Symbol |
Tcf3
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| Gene Name |
transcription factor 3
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| Chromosome |
10
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| MGI Accession ID | show more close |
| Strain of Origin |
129S4/SvJaeSor
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| Molecular Note |
A targeting construct was engineered to contain a 5' loxP site in an intron upstream of the bHLH sequence, common to both E12 and E47 isoforms, and a 3' loxP site downstream of the endogenous locus. Also included in the construct were neo and lacZ genes, respectively positioned upstream and downstream of the 3' loxP site. The construct was designed such that the lacZ gene will be transcribed only upon recombination of the loxP sites.
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| HUSBANDRY | |
|---|---|
| Suggested Controls |
B6129SF1/J
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| Breeding Considerations |
When maintaining a live colony, these mice are bred as homozygotes.
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For Research Use Only.
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