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B6.129S1-Reltm1Ukl/J
Cat. No.: CEMM-07250537
Common Name: relfl/fl
These c-Relfl mutant mice possess loxP and FRT sites flanking exon 1 of the Rel gene. This strain may be useful for generating conditional mutations in applications related to the NF-kB signal transduction pathway. Cre-mediated recombination also results in expression of GFP (Green Fluorescent Protein) which can be used to trace Rel ablation.
Inquiry
| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Reltm1Ukl
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| Allele Name |
targeted mutation 1
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| Allele Attributes |
Conditional ready (e.g. floxed)
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| Gene Symbol |
Rel
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| Gene Name |
reticuloendotheliosis oncogene reticuloendotheliosis oncogene
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| Chromosome |
11
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| Expressed Genes |
GFP, Green Fluorescent Protein
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| MGI Accession ID | show more close |
| Site of Expression |
EGFP will be expressed in cells where promoters driving Cre recombinase are expressed.
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| Strain of Origin |
129S1/Sv-Oca2+ Tyr+ Kitl+
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| Molecular Note |
Sequence encoding a promoterless eGFP minigene, a loxP site and the PGKneo cassette was inserted upstream of exon 1 of the targeted gene, and another loxP site followed by the PGK promoter was inserted downstream of exon 1. The entire targeted region was flanked by FRT sites.
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| HUSBANDRY | |
|---|---|
| Suggested Controls |
C57BL/6J
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| Breeding Considerations |
When maintaining a live colony, these mice can be bred as homozygotes.
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For Research Use Only.
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