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B6.129S1-Is(14C3)3Rdf/J
Cat. No.: CEMM-07250361
These 14qC3-CDRfl mice carry a floxed segment that encompasses sequence corresponding to a common deleted region (CDR) involved in most common B cell chronic lymphocytic leukemias in humans. They have applications in studies related to tumorigenesis and therapeutic management of chronic lymphocytic leukemia.
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| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Is(14)5Rdf
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| Allele Name |
insertion
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| Gene Symbol |
Is(14)5Rdf
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| Gene Name |
insertion
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| Chromosome |
14
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| MGI Accession ID | show more close |
| Site of Expression |
When bred to a strain with Cre recombinase, expression occurs in B lymphocytes.
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| Strain of Origin |
129S1/Sv-Oca2+ Tyr+ Kitl+
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| Molecular Note |
The targeting vector contained a PGK-Hygro cassette, loxP and FRT sites, inserted in the telomeric region of 14qC3, approximately 2 kb centromeric to the last exon of Rnaseh2b gene.
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| HUSBANDRY | |
|---|---|
| Suggested Controls |
C57BL/6J
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| Breeding Considerations |
When maintaining a live colony, these mice can be bred as homozygotes.
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For Research Use Only.
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