C57BL/6N-Tg(Camk2a-HBEGF)BNkza/J

Cat. No.: CEMM-07250489

fDTR-line-B mice express a conditional diphtheria toxin receptor (DTR) under the transcriptional control of the murine CamKIIα promoter. These mice may be useful for neuronal-specific cell ablation.

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Status	Live Mouse Frozen Embryo
Age	4 weeks 12 weeks Customized Age
Sex	Male Female

GENETICS
Allele Symbol	Tg(Camk2a-HBEGF)BNKza show more close
Allele Name	transgene insertion B show more close
Allele Attributes	Conditional ready (e.g. floxed); Inserted expressed sequence show more close
Gene Symbol	Tg(Camk2a-HBEGF)BNKza show more close
Gene Name	transgene insertion B show more close
Chromosome	UN show more close
Expressed Genes	HBEGF, heparin binding EGF like growth factor, human show more close
MGI Accession ID	5523547 show more close
Strain of Origin	C57BL/6N show more close
Molecular Note	A targeting construct contained the Camk2a promoter, a loxp flanked alkaline phosphates-pA stop cassette and the sequence for the human homolog of heparin-binding epidermal growth factor-like growth factor (HBEGF) which functions as a diphtheria toxin receptor (DTR) in mice. Lines A and B were generated with line B exhibiting reduced expression compared with line A. Upon Cre-mediated excision of the floxed AP stop cassette, the DTR is expressed making it possible to ablate specific cell populations. show more close

HUSBANDRY
Suggested Controls	Noncarrier show more close
Breeding Considerations	When maintaining a live colony, hemizygous mice may be bred together. show more close

For Research Use Only.